Cells As Delivery Vehicles for Cancer Therapeutics

Basel, Matthew T.; Shrestha, Tej B.; Bossmann, Stefan H.; Troyer, Deryl L.

doi:10.4155/tde.14.24

Cited by 27 publications

(15 citation statements)

References 99 publications

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“…The ability of certain types of stem and immune cells to target tumors, termed cytotherapeutics, allows their utilization as vectors to deliver several types of anticancer payloads [1,2]. Cells, as opposed to nanoparticles, which are driven by passive concentration gradients, have the ability to target and infiltrate the tumor interstitium by an active process.…”

Section: Background: Cells As Vectors For the Delivery Of Nanoparticlesmentioning

confidence: 99%

Macrophages As Nanoparticle Delivery Vectors for Photothermal Therapy of Brain Tumors

et al. 2015

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Certain types of stem and immune cells, which have an innate ability to target and infiltrate tumors, can be utilized as vectors to deliver several types of anticancer agents. In particular monocytes have the advantage of carrying relatively large payloads of therapeutic nanomaterials, can be patient derived in large numbers and are able to actively infiltrate tumors despite many barriers often present in the microenvironment. Monocytes can selectively cross the compromised blood-brain barrier surrounding brain tumors and are known to actively migrate to hypoxic tumor regions. Of particular interest is the observation that, following near-infrared exposure of tumors containing gold-nanoshell-loaded macrophages, sufficient hyperthermia can be generated to suppress tumor growth. Collectively, these findings demonstrate the potential of monocytes as nanoparticle delivery vectors for several types of site specific light-based cancer therapies.

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Section: Background: Cells As Vectors For the Delivery Of Nanoparticlesmentioning

confidence: 99%

Macrophages As Nanoparticle Delivery Vectors for Photothermal Therapy of Brain Tumors

et al. 2015

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“…The ability of certain types of stem and immune cells to target tumors allows their utilization as vectors to deliver several types of anti-cancer payloads (Fischbach et al 2013; Basel et al 2014). Cells have the ability to target and infiltrate the tumor interstitium by an active process (Fig.…”

Section: Cell Based Delivery Of Nanoparticlesmentioning

confidence: 99%

Cell Mediated Photothermal Therapy of Brain Tumors

Hirschberg

Madsen

2016

J Neuroimmune Pharmacol

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Gold based nanoparticles with strong near infra-red (NIR) absorption are ideally suited for photothermal therapy (PTT) of brain tumors. The goal of PTT is to induce rapid heating in tumor tissues while minimizing thermal diffusion to normal brain. PTT efficacy is sensitively dependent on both nanoparticle concentration and distribution in tumor tissues. Nanoparticle delivery via passive approaches such as the enhanced permeability and retention (EPR) effect is unlikely to achieve sufficient nanoparticle concentrations throughout tumor volumes required for effective PTT. A simple approach for improving tumor biodsitribution of nanoparticles is the use of cellular delivery vehicles. Specifically, this review focuses on the use of monocytes/macrophages (Mo/Ma) as gold nanoparticle delivery vectors for PTT of brain tumors. Although the efficacy of this delivery approach has been demonstrated in both in vitro and animal PTT studies, its clinical potential for the treatment of brain tumors remains uncertain.

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“…The primary goal of post-operative treatment is to reduce or eliminate tumor recurrence due to remaining malignant cells residing in the margin of the resection cavity. Targeted delivery approaches of chemotherapeutic drugs, such as cell-based vectorization, may result in improved outcomes since they can target and maintain elevated drug concentrations at the tumor site and prevent their spread into healthy tissue [1,2]. In contrast to nanoparticles, cells such as monocytes, Ma, and stem cells migrate to and infiltrate into tumors via an active process, despite stromal barriers and the elevated interstitial pressure present in most tumors.…”

Section: Introductionmentioning

confidence: 99%

Photochemical internalization enhanced macrophage delivered chemotherapy

Shin

Christie

et al. 2018

Photodiagnosis and Photodynamic Therapy

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Background Macrophage (Ma) vectorization of chemotherapeutic drugs has the advantage for cancer therapy in that it can actively target and maintain an elevated concentration of drugs at the tumor site, preventing their spread into healthy tissue. A potential drawback is the inability to deliver a sufficient number of drug-loaded Ma into the tumor, thus limiting the amount of active drug delivered. This study examined the ability of photochemical internalization (PCI) to enhance the efficacy of released drug by Ma transport. Methods Tumor spheroids consisting of either F98 rat glioma cells or F98 cells combined with a subpopulation of empty or doxorubicin (DOX)-loaded mouse Ma (RAW264.7) were used as in vitro tumor models. PCI was performed with the photosensitizer AlPcS2a and laser irradiation at 670 nm. Results RAW264.7 Ma pulsed with DOX released the majority of the incorporated DOX within two hours of incubation. PCI significantly increased the toxicity of DOX either as pure drug or derived from monolayers of DOX-loaded Ma. Significant growth inhibition of hybrid spheroids was also observed with PCI even at subpopulations of DOX-loaded Ma as low as 11% of the total initial hybrid spheroid cell number. Conclusion Results show that RAW264.7 Ma, pulsed with DOX, could effectively incorporate and release DOX. PCI significantly increased the ability of both free and Ma-released DOX to inhibit the growth of tumor spheroids in vitro. The growth of F98+DOX loaded Ma hybrid spheroids were synergistically reduced by PCI, compared to either photodynamic therapy or released DOX acting alone.

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Cells As Delivery Vehicles for Cancer Therapeutics

Cited by 27 publications

References 99 publications

Macrophages As Nanoparticle Delivery Vectors for Photothermal Therapy of Brain Tumors

Macrophages As Nanoparticle Delivery Vectors for Photothermal Therapy of Brain Tumors

Cell Mediated Photothermal Therapy of Brain Tumors

Photochemical internalization enhanced macrophage delivered chemotherapy

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