Cells and mediators involved in immunoglobulin synthesis by human circulating mononuclear cells

Postnatal maturation of immune competence during infancy and childhood

“…However, the overall levels of IgG and IgA synthesis achieved with optimal cytokine "help" still remain below those seen in cultures of adult B-cells (49, 63). It has also been suggested that low endogenous "accessory cell" activity in neonatal PBL also contributes to diminished B-cell responses in vitro (64).…”