Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle
Bernard T. Drumm,
Neha Gupta,
Alexandru Mircea
et al.
Abstract:Smooth muscle organs of the lower urinary tract comprise the bladder detrusor and urethral wall, which have a reciprocal contractile relationship during urine storage and micturition. As the bladder fills with urine, detrusor smooth muscle cells (DSMCs) remain relaxed to accommodate increases in intravesical pressure while urethral smooth muscle cells (USMCs) sustain tone to occlude the urethral orifice, preventing leakage. While neither organ displays coordinated regular contractions as occurs in small intest… Show more
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