Cellano-sensibilisierung mit hämolytisch-hämorrhagischem Transfusionszwischenfall

Kluge, A.; Krah, Ernst; Franz, H. E.

doi:10.1007/bf01632627

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…Последняя трансфузионная гемолитическая реакция, обусловленная иммунизацией к KEL2, описана в 1969 г. [8].…”

Section: Discussionunclassified

Erythrocyte antigen kel1 in a new form of disease history

Pokhabov,

Fomina,

Shestakov

et al. 2023

jour

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The accumulated scientific data on the clinical significance of phenotyping antigens of the Kell blood group system were studied. The Elibrary and Pubmed libraries were searched for articles using the keywords “Kell” and “transfusion”, and the validity of the requirement to determine the antigen of the Kell blood group system by current regulations was assessed.The purpose of the determination of the K antigen (KEL1) is practically not very clear. Theoretically, in a K-positive patient, zygosity should be determined by determining the k antigen (KEL2). With the KK phenotype, there is a risk of alloimmunization with the k antigen. However, it is extremely difficult to find a KK-positive donor compatible with ABO and RhD phenotypes. In fact, the risk of alloimmunization with the KEL2 antigen of a KK-positive recipient is considered acceptable and individual donor selection can be made for recipients of multiple transfusions or alloimmunized individuals.In the Elibrary library, 62 publications were found for the term “Kell”. None of them described a patient with the KK phenotype, let alone alloimmunization with the k antigen.Anti-k is rare, even in large laboratories 1 case is detected within several years of observation. The last transfusion hemolytic reaction caused by immunization to KEL2 was described in 1969.Conclusion. Russian regulations require the transfusion of RBCs that are compatible for the KEL1 antigen, but there is no definition of such “compatibility”. World and domestic historical experience testify to the possibility of transfusion to K-positive recipients, both K-positive and K-negative erythrocytes. If there are no K-positive donor erythrocytes in the hospital, the mandatory determination of the KEL1 antigen in potential recipients of donor blood can be excluded.

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“…Последняя трансфузионная гемолитическая реакция, обусловленная иммунизацией к KEL2, описана в 1969 г. [8].…”

Section: Discussionunclassified

Erythrocyte antigen kel1 in a new form of disease history

Pokhabov,

Fomina,

Shestakov

et al. 2023

jour

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“…Her serum was icteric, and 1 + to 2 + agglutination reactions were observed in the IAT for 11 Despite transfusion with eight units of group O or A, D-negative, U-negative RBCs (obtained through the American Red Cross Rare Donor Registry), she developed progressive cardiac, liver, and kidney failure. Clinically, renal failure was attributed to hypotension secondary to acute blood loss, but hemolysis, infection, and/or an adverse drug reaction could not be excluded.…”

Section: Case Reportmentioning

confidence: 99%

Immune-mediated hemolysis in a postoperative patient Case report: anti-U and differential diagnosis

Womack²,

Sg³

1993

Immunohematology

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We present the differential diagnosis for a Coombs-positive immune hemolysis having onset during hospitalization and, in particular, during the postoperative period. The stimulus for this article was a delayed hemolytic transfusion reaction (DHTR) due to anti-U following open-heart surgery. The initial clinical and serologic findings led us to consider other causes of immune hemolysis which are reviewed in this article. To our knowledge, this is the fourth case of a DHTR due to anti-U to be reported in the medical literature. ImmunohematoIogv 1993;9:41-46.

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Immune reactions of platelets and their clinical significance

Mueller-Eckhardt

1975

Klin Wochenschr

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It is recognized that blood platelets with a peculiar cell membrane which carries numerous genetically determined immunogens, but is also intricately associated with the hemostatic process not only participate in immune reactions as a passive target cell, but also as an active functional cell. Pertinent results of animal experiments and of in vivo and in vitro investigations with human blood platelets are reviewed in the attempt to elucidate the role of immune reactions of platelets in the pathogenesis of various human bleeding disorders.

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Cellano-sensibilisierung mit hämolytisch-hämorrhagischem Transfusionszwischenfall

Cited by 4 publications

References 14 publications

Erythrocyte antigen kel1 in a new form of disease history

Erythrocyte antigen kel1 in a new form of disease history

Immune-mediated hemolysis in a postoperative patient Case report: anti-U and differential diagnosis

Immune reactions of platelets and their clinical significance

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