Cell wall melanin impedes growth of theCryptococcus neoformanspolysaccharide capsule by sequestering calcium
Rosanna P. Baker,
Amy Z. Liu,
Arturo Casadevall
Abstract:Cryptococcus neoformanshas emerged as a frontrunner among deadly fungal pathogens and is particularly life-threatening for many HIV-infected individuals with compromised immunity. Multiple virulence factors contribute to the growth and survival ofC. neoformanswithin the human host, the two most prominent of which are the polysaccharide capsule and melanin. As both of these features are associated with the cell wall, we were interested to explore possible cooperative or competitive interactions between these tw… Show more
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