Cell Wall Deficient Bacterial Variants from Man in Experimental Cardiopathy

Merline, Joseph R.; Golden, Alfred; Mattman, Lida H.

doi:10.1093/ajcp/55.2.212

Am J Clin Pathol

1971

DOI: 10.1093/ajcp/55.2.212

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Cell Wall Deficient Bacterial Variants from Man in Experimental Cardiopathy

Joseph R. Merline

Alfred Golden

Lida H. Mattman

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1973

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“…Young and Dahlquist (19) demonstrated that rapid clearing of intravenously injected L-forms of S. aureus occurred in rabbits. Merline et al (10) reportedly showed leukocytic infiltration at the base of heart valves of some mice receiving intravenous injection of epinephrine and cell wall-deficient forms of alpha-hemolytic streptococcus.…”

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Pathogenicity of Stable L-Phase Variants of Staphylococcus aureus : Failure to Colonize Experimental Endocarditis in Rabbits

1973

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Endocarditis was induced in the rabbit by the placement of a polyethylene catheter in the right heart. The catheter was filled with stable L-phase variants of Staphylococcus aureus to determine if the variant form would colonize the damaged endocardium and produce further tissue injury similar to that produced by the vegetative bacterial phase. No L-phase variants were recovered from cultures of blood or vegetations, although pure cultures of L-phase variants were obtained from all catheters, including one in place for 70 days. The vegetations were grossly similar in control animals with sterile media in the catheters and animals with catheters containing L-phase variants, although polymorphonuclear leukocytes and eosinophils were more frequently found in vegetations from animals inoculated with L-phase variants. Endocarditis was also induced in animals with vegetative S. aureus and then treated with penicillin G. Blood cultures in hypertonic media often grew vegetative S. aureus when there was no growth in routine media, but no L-phase variants were detected. Vegetative S. aureus, but not wall-defective variants, were isolated from vegetations of all treated animals. on August 1, 2020 by guest http://iai.asm.org/ Downloaded from 726 INFECT. IMMUNITY on August 1, 2020 by guest http://iai.asm.org/ Downloaded from

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confidence: 99%

Pathogenicity of Stable L-Phase Variants of Staphylococcus aureus : Failure to Colonize Experimental Endocarditis in Rabbits

1973

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Cell Wall Deficient Bacterial Variants from Man in Experimental Cardiopathy

Cited by 1 publication

References 0 publications

Pathogenicity of Stable L-Phase Variants of Staphylococcus aureus : Failure to Colonize Experimental Endocarditis in Rabbits

Pathogenicity of Stable L-Phase Variants of Staphylococcus aureus : Failure to Colonize Experimental Endocarditis in Rabbits

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