Cell-wall-deficient bacteria

Woo, Patrick C. Y.; Wong, S.P.; Lum, Peggy N. L.; Hui, W.C.; Yuen, Kwok‐Yung

doi:10.1016/s0140-6736(00)04993-x

Cited by 2 publications

(3 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With absence of a gold standard for the clinical diagnosis of catheter-related bloodstream infection, we utilized the CDC criterion: the patient has at least one of the following signs or symptoms: fever (>38°C), chills, or hypotension, and the signs and symptoms and positive laboratory results are not related to an infection at another site. Bloodstream infection was defined as one or more positive blood cultures obtained in the presence of clinical features with systemic antibiotics administered for more than 5 days [ 4 , 6 , 9 , 10 ]. Uninfected patients were defined as those who had one or more positive blood cultures but no clinical features of infection.…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies regarding the utility of surveillance blood cultures in patients undergoing hematopoietic stem cell transplantation (HSCT) are scarce with small numbers of patients, and describe specific subgroups of patients in relation to the type of transplant or the patients’ age [ 13 - 17 ]. Moreover, these studies have come to differing conclusions [ 10 - 13 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Utility of surveillance blood cultures in patients undergoing hematopoietic stem cell transplantation

Ghazal

Stevens

Bearman

et al. 2014

Antimicrob Resist Infect Control

View full text Add to dashboard Cite

BackgroundSurveillance blood cultures are often obtained in hematopoietic stem cell transplant (HSCT) patients for detection of bloodstream infection. The major aims of this retrospective cohort study were to determine the utility of the practice of obtaining surveillance blood cultures from asymptomatic patients during the first 100 post-transplant days and to determine if obtaining more than one positive blood culture helps in the diagnosis of bloodstream infection.MethodsWe conducted a 17-month retrospective analysis of all blood cultures obtained for patients admitted to the hospital for HSCT from January 2010 to June 2011. Each patient’s clinical course, vital signs, diagnostic testing, treatment, and response to treatment were reviewed. The association between number of positive blood cultures and the final diagnosis was analyzed.ResultsBlood culture results for 205 patients were reviewed. Cultures obtained when symptoms of infection were present (clinical cultures) accounted for 1,033 culture sets, whereas 2,474 culture sets were classified as surveillance cultures (no symptoms of infection were present). The total number of positive blood cultures was 185 sets (5.3% of cultures obtained) and accounted for 84 positive culture episodes. Incidence of infection in autologous, related allogeneic and unrelated allogeneic transplants was 8.3%, 20.0%, and 28.6% respectively. Coagulase-negative staphylococci were the most common organisms isolated. Based on our application of predefined criteria there were 29 infections and 55 episodes of positive blood cultures that were not infections. None of the patients who developed infection were diagnosed by surveillance blood cultures. None of the uninfected patients with positive blood cultures showed any clinical changes after receiving antibiotics. There was a significant difference between the incidence of BSI in the first and second 50-day periods post-HSCT. There was no association between the number of positive blood cultures and the final diagnosis.ConclusionSurveillance blood cultures in patients who have undergone HSCT do not identify bloodstream infections. The number of positive blood cultures was not helpful in determining which patients had infection. Patients are at higher risk of infection in the first 50 days post-transplant period.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Utility of surveillance blood cultures in patients undergoing hematopoietic stem cell transplantation

Ghazal

Stevens

Bearman

et al. 2014

Antimicrob Resist Infect Control

View full text Add to dashboard Cite

show abstract

“…In this review, we will take the L-form to mean a pleomorphic variant of bacteria with deficient cell wall characteristics that may require hypertonic media, and may revert to a walled organism. 9 We will use the terms CWDB and L-form interchangeably.…”

Section: Introductionmentioning

confidence: 99%

Cell Wall-Deficient Bacteria as a Cause of Infections: A Review of the Clinical Significance

2005

View full text Add to dashboard Cite

Cell wall-deficient bacteria (CWDB) are pleomorphic bacterial forms. These atypical organisms may occur naturally or they can be induced in the laboratory. Their presence has been known about for over a century, but a definite link to clinical disease outcomes has not been demonstrated. A number of case reports and laboratory studies suggest some disease associations, however. Considerable controversy surrounds the true relevance of CWDB to disease; there is a widespread belief that they may represent a response by the walled organism to adverse extracellular conditions like antibiotic pressure. This review looks at studies published between 1934 and 2003, which were identified by Dialog DataStar using the key words 'cell wall deficient bacteria and clinical significance and infections' and by further scanning the reference list at the end of the papers retrieved. We conclude that the evidence for the clinical significance of CWDB in disease is not compelling.

show abstract

Cell-wall-deficient bacteria

Cited by 2 publications

References 2 publications

Utility of surveillance blood cultures in patients undergoing hematopoietic stem cell transplantation

Utility of surveillance blood cultures in patients undergoing hematopoietic stem cell transplantation

Cell Wall-Deficient Bacteria as a Cause of Infections: A Review of the Clinical Significance

Contact Info

Product

Resources

About