Cell‐Wall Alterations as an Attribute of<i>Mycobacterium tuberculosis</i>in Latent Infection

Seiler, Peter; Ulrichs, Timo; Bandermann, Silke; Pradl, Lydia; Jörg, Sabine; Krenn, Veit; Morawietz, Lars; Kaufmann, Stefan H. E.; Aichele, Peter

doi:10.1086/378563

Cited by 144 publications

(136 citation statements)

References 19 publications

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“…Indeed, the low number of AFB observed in focal granulomas by ZN staining was already pointed out by Balseiro et al (2003) and González et al (2005), and it seems to be more related to the difficulties to stain dormant MAP whose cell wall has lost acid-fastness than to absence of this agent in the macrophagic cells (Seiler et al, 2003).…”

Section: Discussionmentioning

confidence: 85%

Latent infections are the most frequent form of paratuberculosis in slaughtered Friesian cattle

Vázquez¹,

Garrido²,

Molina³

et al. 2014

Span. j. agric. res.

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Paratuberculosis is a chronic mycobacterial infection causing granulomatous enteritis in ruminants, whose pathogenesis and epidemiology poses numerous challenges, including latency and reactivation. The most recent and complete classification of paratuberculosis immunopathological types in cattle recognized five categories. In this study, 1031 slaughtered Friesian cattle were submitted to serological, microbiological and pathological examinations with the aim of maximizing the rate of case detection. In most cases, infected animals had minimal lesions and almost no other proof of infection (38.9%), while the more characteristic types with the whole constellation of microbiological and immunological evidences accounted for a lower proportion (7.7%). As these findings in cattle suggest similarities with the epidemiology of tuberculosis in humans, we propose to re-group the original immunopathological types into two broader paratuberculosis epidemio-pathogenic forms or states: latent and patent. The former term would define infections with focal lesions and might constitute an apparent resilience status representing a difficult to detect reservoir of infection whose role could become critical if later immune-compromising factors lead to re-activation. The latter would group those cases with multifocal and diffuse inflammatory lesions with higher mycobacterial load and viability suggestive of a more immediate epidemiological risk. Interestingly, the relative frequency of presentation of each profile varied with age. The proportion of latent forms remained relatively constant between 33.8% and 54.3% through adulthood from 3 years of age, while patent forms were more frequent during the first years of age and tended to decrease among the oldest individuals.

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Section: Discussionmentioning

confidence: 85%

Latent infections are the most frequent form of paratuberculosis in slaughtered Friesian cattle

Vázquez¹,

Garrido²,

Molina³

et al. 2014

Span. j. agric. res.

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“…Sometimes, persistent M. tuberculosis bacteria bearing cell wall alterations may remain undetected by the classic Ziehl-Neelsen staining (Seiler et al, 2003). Appearance of polymorphic non-acid fast forms and coccoids in cultures of mycobacteria has been observed by other authors (Chandrasekhar & Ratnam , 1992;Csillag, 1964;Juhasz, 1962;Miller, 1932;Xalabarder, 1958).…”

Section: L-conversion Morphology and Ultrastructurementioning

confidence: 83%

Cell Wall Deficiency in Mycobacteria: Latency and Persistence

Маркова¹

2012

Understanding Tuberculosis - Deciphering the Secret Life of the Bacilli

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“…Ziehl-Neelsennegative bacilli can be detected in chronically infected mice as well as in non-progressive human tuberculous lung lesions [50]. In contrast, M. tuberculosis present in cavernous cavities with access to the bronchial system and thus to an ample oxygen supply, appear ZN-positive, are coughed up, and are stained in sputum of patients with active TB.…”

Section: Transition Of M Tuberculosis Into a Dormant State Within Grmentioning

confidence: 99%

New insights into the function of granulomas in human tuberculosis

Ulrichs

Kaufmann

2005

The Journal of Pathology

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350

345

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The human tuberculous granuloma provides the morphological framework for local immune processes central to the outcome of tuberculosis. This review article describes investigations on human lung granulomas aimed at better understanding the regional host response and counter-measures to Mycobacterium tuberculosis. These findings lead to a revised view of the regional immune response in human tuberculosis. Novel insights into this dynamic cross-talk form the basis of novel intervention strategies.

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Cell‐Wall Alterations as an Attribute ofMycobacterium tuberculosisin Latent Infection

Cited by 144 publications

References 19 publications

Latent infections are the most frequent form of paratuberculosis in slaughtered Friesian cattle

Latent infections are the most frequent form of paratuberculosis in slaughtered Friesian cattle

Cell Wall Deficiency in Mycobacteria: Latency and Persistence

New insights into the function of granulomas in human tuberculosis

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