Cell type-specific expression of estrogen and progesterone receptors in the human vaginal mucosa

Gu, Chao; Duluc, Dorothée; Wiest, Matthew; Xue, Yaming; Yi, Johnny; Gorvel, Jean‐Pierre; Joo, HyeMee; Oh, SangKon

doi:10.1016/j.clim.2021.108874

Cited by 5 publications

(1 citation statement)

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“…Increased vaginal epithelial cell layer increases ERα and ERβ expression [37]. The expression of ERα and ERβ, markers of improved vaginal dryness, were detected based on H&E staining, and ERα levels were found to be higher in all administration groups compared to the OVX group; the higher the ratio and concentration of PS and the more complex the extracts, the greater the effect (Figure 3A,B).…”

Section: Complex Extract Of Ps and Ns Increased Erα And Erβ Expressio...mentioning

confidence: 95%

Complex Extract of Polygonatum sibiricum and Nelumbinis semen Improves Menopause Symptoms via Regulation of Estrogen Receptor Beta in an Ovariectomized Rat Model

et al. 2023

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Menopause is a hormone-deficiency state that causes facial flushing, vaginal dryness, depression, anxiety, insomnia, obesity, osteoporosis, and cardiovascular disease as ovarian function decreases. Hormone-replacement therapy is mainly used to treat menopause; however, its long-term use is accompanied by side effects such as breast cancer and endometriosis. To identify the effect of a complex extract of Polygonatum sibiricum (PS) and Nelumbinis semen (NS) on improving menopause without side effects, an ovariectomized rat model was established to analyze several menopause symptoms. Compared to single extracts, the complex extract restored vaginal epithelial cell thickness and decreased serotonin concentration by increasing the estrogen receptors ERα (ESR1) and ERβ (ESR2), depending on the ratio. Although the complex extract exerted a lower weight-loss effect than the single extracts, improved blood-lipid metabolism was observed after increasing high-density lipoprotein cholesterol levels and decreasing low-density lipoprotein cholesterol and triglyceride levels, and ovariectomy-induced osteoporosis was alleviated by suppressing osteoclast production. Thus, by increasing only ERβ expression without regulating ERα expression in the uterus, the complex extract of PS and NS may be a natural treatment for improving menopause symptoms without side effects, such as endometriosis.

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Section: Complex Extract Of Ps and Ns Increased Erα And Erβ Expressio...mentioning

confidence: 95%