Cell transplantation to prevent heart failure: a comparison of cell types

Fujii, Takeshiro; Yau, Terrence M.; Weisel, Richard D.; Ohno, Nobuhisa; Mickle, Donald A.G.; Shiono, Noritsugu; Ozawa, Tsukasa; Matsubayashi, Keiji; Li, Ren‐Ke

doi:10.1016/s0003-4975(03)01013-0

Cited by 47 publications

(34 citation statements)

References 22 publications

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“…Laham et al (93) and Pearlman et al (90) showed on MR imaging that intra-pericardial delivery of FGF-2 and VEGF reduced the extent of the hypoperfused zone and improved myocardial perfusion. Others focused on the use of cells (94,95) and genes that regulate the activity of multiple angiogenic growth factors, such as VEGF-A, VEGFR-1 (96), TGF 3 (96,97), IGF 2 (98) and erythropoietin (99). Administration of progenitor cells, myocytes, adipocytes, fibroblasts or smooth muscle cells improves myocardial perfusion and function in infracted myocardium (94,95).…”

Section: Feasibility Of Mr Studies Animal Studiesmentioning

confidence: 99%

“…They found that G-CSF caused no improvement in LV function. Several studies (94,95,110,111) have used progenitor cells, myocytes, adipocytes, fibroblasts, or smooth muscle cells in patients (Table 2) (79,80,109,(112)(113)(114)(115)(116). Three randomized controlled studies (79,80,115) have been published using bone marrow cells for promoting angiogenesis.…”

Section: Clinical Studiesmentioning

confidence: 99%

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MR imaging in assessing cardiovascular interventions and myocardial injury

Jacquier

Higgins

Saeed

2007

Contrast Media & Molecular

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Performing an MR-guided endovascular intervention requires (1) real-time tracking and guidance of catheters/guide wires to the target, (2) high-resolution images of the target and its surroundings in order to define the extent of the target, (3) performing a therapeutic procedure (delivery of stent or injection of gene or cells) and (4) evaluating the outcome of the therapeutic procedure. The combination of X-ray and MR imaging (XMR) in a single suite was designed for new interventional procedures. MR contrast media can be used to delineate myocardial infarcts and microvascular obstruction, thereby defining the target for local delivery of therapeutic agents under MR-guidance. Iron particles, or gadolinium- or dysprosium-chelates are mixed with the soluble injectates or stem cells in order to track intramyocardial delivery and distribution. Preliminary results show that genes encoded for vascular endothelial and fibroblast growth factor and cells are effective in promoting angiogenesis, arteriogenesis, perfusion and LV function. Angiogenic growth factors, genes and cells administered under MR-guided minimally invasive catheter-based procedures will open up new avenues in treating end-stage ischemic heart disease. The optimum dose of the therapeutic agents, delivery devices and real-time imaging techniques to guide the delivery are currently the subject of ongoing research. The aim of this review is to (1) provide an updated review of experiences using MR imaging to guide transcatheter therapy, (2) address the potential of cardiovascular magnetic resonance (MR) imaging and MR contrast media in assessing myocardial injury at a molecular level and labeling cells and (3) illustrate the applicability of the non-invasive MR imaging in the field of angiogenic therapies through recent clinical and experimental publications.

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Section: Feasibility Of Mr Studies Animal Studiesmentioning

confidence: 99%

Section: Clinical Studiesmentioning

confidence: 99%

MR imaging in assessing cardiovascular interventions and myocardial injury

Jacquier

Higgins

Saeed

2007

Contrast Media & Molecular

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“…24,25 These studies were informative, because they suggested that noncontractile effects might be at play in cell-based repair. An emerging hypothesis has been called the "paracrine effect," whereby transplanted cells are proposed to produce growth factors, cytokines, and other local signaling molecules that are beneficial to the infarct.…”

Section: The Early Years: Transplantation Of Committed Cells In Preclmentioning

confidence: 99%

Cell-Based Cardiac Repair

2005

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“…[1][2][3][4] However, improvements in ventricular function were less impressive in the clinical trials than in animal studies, perhaps due to advanced age and comorbidities in the patients. Identifying the mechanisms responsible for the functional improvements may permit clinicians to adapt cell therapies for elderly patients.…”

mentioning

confidence: 99%

Skeletal Myoblasts Preserve Remote Matrix Architecture and Global Function When Implanted Early or Late After Coronary Ligation Into Infarcted or Remote Myocardium

et al. 2008

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Background-The inability of skeletal myoblasts to transdifferentiate into cardiomyocytes suggests that their beneficial effects on cardiac function after a myocardial infarction are mediated by paracrine effects. We evaluated the roles of these factors in the preservation of matrix architecture (in the infarct and remote regions) by varying the timing (postmyocardial infarction) and delivery site of the implanted cells. Methods and Results-Skeletal myoblasts (5ϫ10 6 ) or control media were injected into the infarct or noninfarcted myocardium at 5 or 30 days after coronary artery ligation in rats. Function was assessed by echocardiography before transplantation and 14 and 30 days thereafter and with a Millar catheter at 30 days after transplantation. Ventricular geometry, remote fibrillar collagen architecture, and changes in the matrix metalloproteinase-TIMP system were evaluated. Myoblast implantation in both sites and at both times preserved matrix architecture (length and width of collagen fibers) in the remote myocardium (in association with some decreases in remote myocardial matrix metalloprotease activity), improved global cardiac function, and attenuated the progressive increase in end diastolic volume (PϽ0.05 for all measures compared with medium controls). Cells delivered into the infarct region preserved scar thickness; cells delivered into the noninfarcted myocardium preserved wall thickness. Conclusions-Regardless of whether the cells were injected into the infarct or the noninfarcted myocardium early after an myocardial infarction or later, skeletal myoblasts improved cardiac function by preventing ventricular dilation and preserving matrix architecture in the remote region, likely mediated by paracrine effects. (Circulation. 2008;118[suppl 1]:S130-S137.)

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Cell transplantation to prevent heart failure: a comparison of cell types

Cited by 47 publications

References 22 publications

MR imaging in assessing cardiovascular interventions and myocardial injury

MR imaging in assessing cardiovascular interventions and myocardial injury

Cell-Based Cardiac Repair

Skeletal Myoblasts Preserve Remote Matrix Architecture and Global Function When Implanted Early or Late After Coronary Ligation Into Infarcted or Remote Myocardium

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