Cell transplantation therapy in reanimating severely head-injured patients

Селедцов, В. И.; Rabinovich, S. S.; Parlyuk, O. V.; Kafanova, M. Yu.; Астраков, С. В.; Селедцова, Г. В.; Самарин, Д. М.; Poveschenko, Olga V.

doi:10.1016/j.biopha.2005.01.012

Cited by 18 publications

(10 citation statements)

References 15 publications

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“…Data suggest that cell therapy is a safe method and can be effectively used for stroke (308), acute brain injury (346,347), and cerebral palsy (345). In addition, neurological function has been restored after autologous neural stem cell transplantation in patients with brain trauma (428).…”

Section: Clinical Studies Of Cell-based Neurorestoratology In Cns Dismentioning

confidence: 99%

Cell Therapy from Bench to Bedside Translation in CNS Neurorestoratology Era

2010

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Recent advances in cell biology, neural injury and repair, and the progress towards development of neurorestorative interventions are the basis for increased optimism. Based on the complexity of the processes of demyelination and remyelination, degeneration and regeneration, damage and repair, functional loss and recovery, it would be expected that effective therapeutic approaches will require a combination of strategies encompassing neuroplasticity, immunomodulation, neuroprotection, neurorepair, neuroreplacement, and neuromodulation. Cell-based restorative treatment has become a new trend, and increasing data worldwide have strongly proven that it has a pivotal therapeutic value in CNS disease. Moreover, functional neurorestoration has been achieved to a certain extent in the CNS clinically. Up to now, the cells successfully used in preclinical experiments and/or clinical trial/treatment include fetal/embryonic brain and spinal cord tissue, stem cells (embryonic stem cells, neural stem/progenitor cells, hematopoietic stem cells, adipose-derived adult stem/precursor cells, skin-derived precursor, induced pluripotent stem cells), glial cells (Schwann cells, oligodendrocyte, olfactory ensheathing cells, astrocytes, microglia, tanycytes), neuronal cells (various phenotypic neurons and Purkinje cells), mesenchymal stromal cells originating from bone marrow, umbilical cord, and umbilical cord blood, epithelial cells derived from the layer of retina and amnion, menstrual bloodderived stem cells, Sertoli cells, and active macrophages, etc. Proof-of-concept indicates that we have now entered a new era in neurorestoratology.

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Section: Clinical Studies Of Cell-based Neurorestoratology In Cns Dismentioning

confidence: 99%

Cell Therapy from Bench to Bedside Translation in CNS Neurorestoratology Era

2010

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“…It is postulated to act through several possible mechanisms, including production of trophic factors, direct cell-to-cell interactions, and functional differentiation and integration into host neuronal circuits [59]. Evidence for cell transplantation in children is limited to two case series [60, 61], both of which were largely in adults. Individuals who showed no recovery of consciousness 5–8 weeks post-injury were transplanted with fetal brain cells and liver hematopoietic cells from aborted (spontaneous or induced) fetuses.…”

Section: Non-pharmacological Interventionsmentioning

confidence: 99%

“…Individuals who showed no recovery of consciousness 5–8 weeks post-injury were transplanted with fetal brain cells and liver hematopoietic cells from aborted (spontaneous or induced) fetuses. The first series [60] included one 17-year-old male and one 18-year-old female, both of whom had significant recovery after transplantation. Follow-up brain imaging (by MRI) demonstrated reversal of early brain atrophy, six months post-transplant in the 18-year old.…”

Section: Non-pharmacological Interventionsmentioning

confidence: 99%

A Narrative Review of Pharmacologic and Non-pharmacologic Interventions for Disorders of Consciousness Following Brain Injury in the Pediatric Population

Evanson

Paulson

Kurowski

2016

Curr Phys Med Rehabil Rep

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Traumatic brain injury (TBI) is the most common cause of long-term disability in the United States. A significant proportion of children who experience a TBI will have moderate or severe injuries, which includes a period of decreased responsiveness. Both pharmacological and non-pharmacological modalities are used for treating disorders of consciousness after TBI in children. However, the evidence supporting the use of potential therapies is relatively scant, even in adults, and overall, there is a paucity of study in pediatrics. The goal of this review is to describe the state of the science for use of pharmacologic and non-pharmacologic interventions for disorders of consciousness in the pediatric population.

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“…Neurological diseases include amyotrophic lateral sclerosis (ALS) [116][117][118] , cerebral palsy (CP) [119,120] , cerebral atrophy [121] , Huntington's Disease [122,123] , and PD [124][125][126] . With respect to CNS injury, spinal cord injury (SCI) [127] and traumatic brain injury [128] have been recent topics in the setting of fetal cell transplantation. Some of these reports are described below.…”

Section: Changes Within the Last Decadementioning

confidence: 99%

Fetal stem cell transplantation: Past, present, and future

Ishii

Eto

2014

WJSC

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Since 1928, human fetal tissues and stem cells have been used worldwide to treat various conditions. Although the transplantation of the fetal midbrain substantia nigra and dopaminergic neurons in patients suffering from Parkinson's disease is particularly noteworthy, the history of other types of grafts, such as those of the fetal liver, thymus, and pancreas, should be addressed as there are many lessons to be learnt for future stem cell transplantation. This report describes previous practices and complications that led to current clinical trials of isolated fetal stem cells and embryonic stem (ES) cells. Moreover, strategies for transplantation are considered, with a particular focus on donor cells, cell processing, and the therapeutic cell niche, in addition to ethical issues associated with fetal origin. With the advent of autologous induced pluripotent stem cells and ES cells, clinical dependence on fetal transplantation is expected to gradually decline due to lasting ethical controversies, despite landmark achievements.

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Cell transplantation therapy in reanimating severely head-injured patients

Cited by 18 publications

References 15 publications

Cell Therapy from Bench to Bedside Translation in CNS Neurorestoratology Era

Cell Therapy from Bench to Bedside Translation in CNS Neurorestoratology Era

A Narrative Review of Pharmacologic and Non-pharmacologic Interventions for Disorders of Consciousness Following Brain Injury in the Pediatric Population

Fetal stem cell transplantation: Past, present, and future

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