Cell transplantation therapies for spinal cord injury focusing on bone marrow mesenchymal stem cells: Advances and challenges

Huang, Lian‐Hua; Sun, Xin; Pan, Hongxia; Wang, Lu; He, Chengqi; Wei, Quan

doi:10.4252/wjsc.v15.i5.385

Cited by 8 publications

(1 citation statement)

References 129 publications

(136 reference statements)

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“…Bone-marrow-derived stem cells (BMDSCs) are multipotent stem cells that can differentiate into different functional cells. Due to their easy acquisition in adult bone marrow, these cells have emerged as an important candidate for stem cell therapy in various diseases [44][45][46]. In 2011, Nagori et al [47] reported a successful pregnancy in a patient with refractory intrauterine adhesions through the autologous transplantation of BMDSCs.…”

Section: Bmdscsmentioning

confidence: 99%

An Update on Experimental Therapeutic Strategies for Thin Endometrium

Tang,

Frisendahl,

Lalitkumar

et al. 2023

Endocrines

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Infertility caused by a thin endometrium remains a significant challenge in assisted reproduction and is often associated with a low success rate after treatment with assisted reproductive technology. There is a lack of consensus in the field concerning both its diagnostic criteria and clinical management. The currently available treatment options are few with limited efficacy. Recent advances in cell therapy and bioengineering have, however, shown promising results for the treatment of a thin endometrium. Notably, these novel interventions have demonstrated the ability to increase endometrial thickness, restore endometrial function, and improve reproductive outcomes. In this comprehensive review, we focus on a critical evaluation of these emerging therapeutic strategies for a thin endometrium including platelet-rich plasma, exosomes derived from stem cells, and bioengineering-based techniques. By synthesizing the findings from available clinical trials, we highlight the promising outcomes achieved so far and underscore the importance of robust clinical trials in assessing the safety and efficacy of these interventions in the future. Continued research efforts to unravel the intricate mechanisms involved in endometrial repair and regeneration will also be essential to enhance our understanding of this multifactorial condition and to identify novel treatment targets for future therapeutic interventions.

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