Cell transplantation therapies for spinal cord injury focusing on induced pluripotent stem cells

Nakamura, Masaya; Okano, Hideyuki

doi:10.1038/cr.2012.171

Cited by 179 publications

(148 citation statements)

References 52 publications

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“…34 Recently, hiPSC (201B7 line) neurospheres were also successfully transplanted into a nonhuman primate SCI injury model, resulting in a functional recovery with no sign of tumor formation. 43,44 The neurospheres promoted significant functional recovery with no tumor formation for ≤3 months after transplantation. 43,44 In summary, NS/PCs were induced from mouse and hiPSCs and transplanted into mouse and/or nonhuman primate SCI models.…”

Section: Transplantation Of Hipsc-derived Ns/pcs Promoted Functional mentioning

confidence: 99%

Steps Toward Safe Cell Therapy Using Induced Pluripotent Stem Cells

Okano¹,

Nakamura²,

Yoshida³

et al. 2013

Circulation Research

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377

292

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Section: Transplantation Of Hipsc-derived Ns/pcs Promoted Functional mentioning

confidence: 99%

Steps Toward Safe Cell Therapy Using Induced Pluripotent Stem Cells

Okano¹,

Nakamura²,

Yoshida³

et al. 2013

Circulation Research

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377

292

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“…To this end, numerous approaches have been undertaken utilizing embryonic stem (ES) cells or induced pluripotent stem cells. Each of these approaches has the advantage that large-scale production of transplantable cells is possible, although at significant cost as well as ethical and safety concerns [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Human and Murine Very Small Embryonic-Like Cells Represent Multipotent Tissue Progenitors, In Vitro and In Vivo

Havens

Sun

Shiozawa

et al. 2014

Stem Cells and Development

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“…[7][8][9]13,14 However, concerns have been raised over the safety of this experimental therapeutic approach. 8 Most concerning is whether de novo tumors can develop from transplanted stem cells or supporting cells.…”

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confidence: 99%

Autograft-derived spinal cord mass following olfactory mucosal cell transplantation in a spinal cord injury patient

Dlouhy¹,

Awe²,

Rao

et al. 2014

SPI

150

106

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Over the last decade, human cell transplantation and neural stem cell trials have examined the feasibility and safety of these potential therapies for treatment of a variety of neurological disorders. However, significant safety concerns have surrounded these trials due to the possibility of ectopic, uncontrolled cellular growth and tumor formation. The authors present the case of an 18-year-old woman who sustained a complete spinal cord injury at T10–11. Three years after injury, she remained paraplegic and underwent olfactory mucosal cell implantation at the site of injury. She developed back pain 8 years later, and imaging revealed an intramedullary spinal cord mass at the site of cell implantation, which required resection. Intraoperative findings revealed an expanded spinal cord with a multicystic mass containing large amounts of thick mucus-like material. Histological examination and immunohistochemical staining revealed that the mass was composed mostly of cysts lined by respiratory epithelium, submucosal glands with goblet cells, and intervening nerve twigs. This is the first report of a human spinal cord mass complicating spinal cord cell transplantation and neural stem cell therapy. Given the prolonged time to presentation, safety monitoring of all patients with cell transplantation and neural stem cell implantation should be maintained for many years.

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Cell transplantation therapies for spinal cord injury focusing on induced pluripotent stem cells

Cited by 179 publications

References 52 publications

Steps Toward Safe Cell Therapy Using Induced Pluripotent Stem Cells

Steps Toward Safe Cell Therapy Using Induced Pluripotent Stem Cells

Human and Murine Very Small Embryonic-Like Cells Represent Multipotent Tissue Progenitors, In Vitro and In Vivo

Autograft-derived spinal cord mass following olfactory mucosal cell transplantation in a spinal cord injury patient

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