Cell transplantation inhibits inflammatory reaction and stimulates repair processes in burn wound

Abstract

We compared the effects of transplantation of fetal fibroblasts and fibroblast-like mesenchymal stem cells of the bone marrow on healing of deep burn wound in rats. It was found that transplantation of fetal fibroblasts and fibroblast-like mesenchymal stem cells on the burn surface reduces cell infiltration, promotes the formation of vessels and granulation tissue, which creates conditions for more rapid healing of the burn wounds.

Potential of mesenchymal stem cells as immune therapy in solid-organ transplantation

“…This capacity makes them promising candidates for use in regenerative medicine. Human and animal studies have shown that MSCs have potential to repair bone [12,13], cartilage [14,15], skin [16,17], and neuronal tissue [18] and improve the function of cardiac muscle [19–21] and the kidney [22]. Recent clinical trials are investigating the use of MSCs in treating heart disease, liver cirrhosis and bone fractures.…”

Experimental stem cell therapies on burn wound: Do source, dose, timing and method matter?

“…Because burn wound is convenient for local application in most of the reviewed studies MSCs have been transplanted by local injection wound or peri-wound area or topical dripping. Some authors have chosen topical dripping of the stem cells onto burn wound [44,48]. Although burn wound is accessible for local dripping of MSCs, because of uncontrollable nature of cell suspensions, the engraftment efficiency can be varied by dripping.…”

“…Singer et al [46] used same amount of cells for the larger stasis zone. Rasulov et al [48] have reported accelerated wound healing by using only 200 cells/cm 2 . Fu et al [47] have showed beneficial effect of MSC on burn wound healing in 2 Â 10 5 cells/cm 2 .…”

“…Administration of MSCs on coagulation zone in early phase of burn injury will soon end up with death of the engrafted MSCs. If MSCs are transplanted by dripping on burn wound, it must be done on the 2 or 3 day after burn by removal of necrotic tissues [44,48]. If MSCs are intended to be transplanted right after burn injury, the injection of the cells to the unburned dermal tissue or implantation on cell protective scaffold can be chosen [42].…”

Potential of stem cells for skin regeneration following burns

“…Adult stem cell therapy reduces the intensity of inflammatory cell infiltration and activates the vessel formation. Thus, it promotes normal interactions between cell assemblies during the regeneration of burn wounds, which prevents the formation of cicatrix or the deformation of tissues [24,25].…”