Cell transplantation in non-ischemic dilated cardiomyopathy

Ohno, Nobuhisa; Fedak, Paul W.M.; Weisel, Richard D.; Komeda, Masashi; Mickle, Donald A.G.; Li, Ren‐Ke

doi:10.1007/bf02919635

Jpn J Thorac Caridovasc Surg

2002

DOI: 10.1007/bf02919635

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Cell transplantation in non-ischemic dilated cardiomyopathy

Nobuhisa Ohno

Paul W.M. Fedak

Richard D. Weisel

et al.

Abstract: This novel approach can be a clinically applicable biological therapy for patients with progressive DCM. More studies to uncover the specific molecular and cellular effects of cell transplantation on the host myocardium are necessary for future clinical application.

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Cited by 7 publications

References 18 publications

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Cardiovascular surgery for realization of regenerative medicine

Masumoto

Sakata

2012

Gen Thorac Cardiovasc Surg

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Regenerative medicine is emerging as a new approach to the treatment of severe cardiovascular diseases that are resistant to conventional therapies. Although the type of cell transplanted (e.g., pluripotent stem cells, bone marrow-derived stem cells, skeletal myoblasts, or cardiac stem cells) influences the outcome of stem cell transplantation, the method of transplantation is also important, as the efficiency of engraftment after simple needle injection is poor. Scaffold-free cell sheet transplantation technology is one of the most promising methods in this regard. Although the results of clinical trials of stem cell therapy have been marginal to date, further elucidation of the actual mechanisms of cardiac repair following cell therapy would enhance the potential for full-scale implementation of stem cell therapy. In addition to stem cell therapy, the field of cardiovascular regenerative medicine includes interspecific chimera technology, drug delivery systems using biodegradable materials, and gene therapy. Integration of these new modalities with conventional therapies will be important to realize the goal of cardiovascular regenerative medicine tailored to the condition of each individual patient. Cardiovascular surgery would be an excellent means of carrying out this strategy and could potentially resolve the health problems of the increasing number of advanced cardiovascular patients. Herein, we review the recent basic and clinical research associated with the realization of regenerative medicine in the field of cardiovascular surgery.

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Cardiovascular surgery for realization of regenerative medicine

Masumoto

Sakata

2012

Gen Thorac Cardiovasc Surg

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Cardiac remodeling and failure

Fedak

Verma

Weisel

et al. 2005

Cardiovascular Pathology

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Given the lack of a unified theory of heart failure, future research efforts will be required to unify and synthesize our current understanding of the multiple mechanisms that control remodeling in the failing heart. Matrix remodeling and the associated activation of inflammatory cytokines and MMPs have emerged as key pathways in the development of heart failure. As such, attempts to understand the integrated control of ECM homeostasis with the bioactivation of inflammatory cytokines may be of particular relevance to the development of effective anti-remodeling approaches. Notably, the implantation of isolated populations of cells in failing myocardium has a profound and consistent anti-remodeling effect that limits the progression to CHF. These observations were consistently identified in numerous studies using diverse experimental animal models and varied cell types. Accordingly, multicenter clinical trials are underway, and the preliminary data in patients with CHF are encouraging. Despite the enormous promise of cell transplantation to restore and regenerate failing myocardium, the mechanisms underlying these profound biological effects are not understood. An improved understanding of the myocardial response to cell implantation, particularly on parameters of matrix remodeling, may help unify our current understanding of the progression of heart failure and optimize the development of this technique for its evolving therapeutic use. The following review outlines recent advances in medical and surgical approaches to control the remodeling process that underlies the progression of heart failure.

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Restoration and regeneration of failing myocardium with cell transplantation and tissue engineering

Fedak

Weisel

Verma

et al. 2003

Seminars in Thoracic and Cardiovascular Surgery

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Cell transplantation in non-ischemic dilated cardiomyopathy

Abstract: This novel approach can be a clinically applicable biological therapy for patients with progressive DCM. More studies to uncover the specific molecular and cellular effects of cell transplantation on the host myocardium are necessary for future clinical application.

Cited by 7 publications

References 18 publications

Cardiovascular surgery for realization of regenerative medicine

Cardiovascular surgery for realization of regenerative medicine

Cardiac remodeling and failure

Restoration and regeneration of failing myocardium with cell transplantation and tissue engineering

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