Cell therapy with autologous platelet rich plasma in the treatment of chronic venous leg ulcers. preliminary results of a prospective randomised phase 2 trial

Otero, Gabriela; Sujanov, A.; Falco, Sara; Echarte, L.; Lamela, N.; Marquisa, N.; Dutra, Daniela Bassi; Rodríguez, Ismael; Touriño, Cristina

doi:10.1016/j.jcyt.2018.02.348

Cited by 1 publication

(3 citation statements)

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“…There was highly significant improvement in PUSH score of ulcers compared to controls ( P value = .001). This result coincided with previous studies which used PG as a treatment for VLUs 8,9 . In group (II), 70% of cases showed complete healing of ulcer.…”

Section: Discussionsupporting

confidence: 91%

“…These fractions were platelet poor plasma in the upper half and PRP in the lower half. Each fraction was separated into different sterile syringes 8 …”

Section: Methodsmentioning

confidence: 99%

“…This result coincided with previous studies which used PG as a treatment for VLUs. 8,9 In group (II), 70% of cases showed complete healing of ulcer. There was highly significant improvement in PUSH score of ulcers compared to controls (P value = .001).…”

Section: Histopathological Evaluationmentioning

confidence: 99%

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Evaluation of safety and efficacy of autologous topical platelet gel vs platelet rich plasma injection in the treatment of venous leg ulcers: A randomized case control study

Elgarhy

El-Ashmawy

Bedeer

et al. 2020

Dermatologic Therapy

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Various management options were tried for Chronic venous leg ulcers (VLUs) with no satisfactory results. Platelet-rich plasma (PRP) is promising in enhancing chronic wound healing by releasing various growth factors. We evaluated the safety and efficacy of topical platelet gel (PG) vs PRP injection in treatment of venous leg ulcers. 20 patients were treated with topical PG (group I), 20 patients received PRP injection (group II), and 20 patients were treated with saline dressing and compression as controls (group III) weekly for 6 weeks. Ulcer improvement was evaluated by pressure ulcer scale for healing (PUSH). Histopathological evaluation and immunohistochemical staining using anti-CD34 were performed before and after treatment. There was significant improvement in PUSH score in group (I) and (II) compared to group (III; P value: .001). However, there was no statistically significant difference in improvement between group I and II (P value = .83). However, topical PG was more effective in diabetics and PRP was more effective in long standing fibrosed ulcers. Histopathology showed reduction of the inflammatory cells infiltrates and well-formed granulation tissue with no difference in immunostaining. So, both topical PG and PRP injection were effective, low cost, and safe procedures in enhancing healing of chronic VLUs.

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Section: Discussionsupporting

confidence: 91%

“…These fractions were platelet poor plasma in the upper half and PRP in the lower half. Each fraction was separated into different sterile syringes 8 …”

Section: Methodsmentioning

confidence: 99%