Cell therapy must be regulated as medicine

Li, Zihai; Liu, Delong

doi:10.1186/s40164-016-0055-0

Cited by 4 publications

(3 citation statements)

References 8 publications

(7 reference statements)

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“…Remarkably, when CAT was added 24 hours after, both Dox‐ and Dauno‐containing medium with QD, returned to basal intensity levels (Supporting Information Figure S6) confirming that the intensity modulation is indeed induced by the presence of ROS such as the superoxide (O 2 − ) radical. Further mechanistic details about this and similar charge transfer and/or resonant energy‐transfer‐mediated intensity modulation of QD fluorescence have been presented by others and recently by ourselves elsewhere .…”

Section: Resultssupporting

confidence: 57%

Fluorescence intensity modulation of CdSe/ZnS quantum dots assesses reactive oxygen species during chemotherapy and radiotherapy for cancer cells

Lee¹,

Suresh²,

Ekpenyong³

2018

Journal of Biophotonics

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Quantum dots (QDs) are semiconductor nanoparticles ranging in size from 2 to 10 nm. QDs are increasingly being developed for biomedical imaging, targeted drug delivery and green energy technology. These have led to much research on QD interactions with various physical, chemical and biological systems. For biological systems, research has focused on the biocompatibility/cytotoxicity of QDs in the context of imaging/therapy. However, there is a paucity of work on how biological systems and bioactive molecules might be used to alter the optoelectronic properties of QDs. Here, it is shown that these properties can be altered by reactive oxygen species (ROS) from chemotherapeutic media and biological cells following controlled changes in cellular activities. Using CdSe/ZnS core-shell QDs, spectroscopic analysis of optically excited QDs with HL60, K562 and T98G cancer cell lines is performed. Our results show statistically significant (P < 0.0001) modulation of the fluorescence emission spectra of the QDs due to the ROS produced by common chemotherapeutic drugs, daunorubicin and doxorubicin and by cells following chemotherapy/radiotherapy. This optical modulation, in addition to assessing ROS generation, will possibly enhance applications of QDs in simultaneous diagnostic imaging and nanoparticle-mediated drug delivery as well as simultaneous ROS assessment and radiosensitization for improved outcomes in cancer treatments. Reactive molecular species produced by biological cells and chemotherapeutic drugs can create electric fields that alter the photophysical properties of QDs, and this can be used for concurrent monitoring of cellular activities, while inducing changes in those cellular activities. K E Y W O R D Scancer, chemotherapy, fluorescence, quantum dot, radiotherapy, reactive oxygen species

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Section: Resultssupporting

confidence: 57%

Fluorescence intensity modulation of CdSe/ZnS quantum dots assesses reactive oxygen species during chemotherapy and radiotherapy for cancer cells

Lee¹,

Suresh²,

Ekpenyong³

2018

Journal of Biophotonics

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“…It is possible that the number of institutions carrying out CAR-T trials will increase at a slower pace once regulatory policies are in place. We believe these CAR-T cells should be regulated as drugs [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

Clinical trials of CAR-T cells in China

2017

Self Cite

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Novel immunotherapeutic agents targeting tumor-site microenvironment are revolutionizing cancer therapy. Chimeric antigen receptor (CAR)-engineered T cells are widely studied for cancer immunotherapy. CD19-specific CAR-T cells, tisagenlecleucel, have been recently approved for clinical application. Ongoing clinical trials are testing CAR designs directed at novel targets involved in hematological and solid malignancies. In addition to trials of single-target CAR-T cells, simultaneous and sequential CAR-T cells are being studied for clinical applications. Multi-target CAR-engineered T cells are also entering clinical trials. T cell receptor-engineered CAR-T and universal CAR-T cells represent new frontiers in CAR-T cell development. In this study, we analyzed the characteristics of CAR constructs and registered clinical trials of CAR-T cells in China and provided a quick glimpse of the landscape of CAR-T studies in China.

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“…Whole blood transfusion, arguably the earliest form of cell therapy, 31 can be seen as a success story for a well-managed biological supply chain. Annually, 6.8 million Americans donate blood, which results in the transfusion of approximately 21 million blood components in the same calendar year, 32 The success is in part due to the 42-day shelf-life of red blood cells at 1-6°C that affords some flexibility in planning the collection, storage, and distribution of the fresh material.…”

Section: Biological Considerations For Logistics Within a Global Supp...mentioning

confidence: 99%

Shipping and Logistics Considerations for Regenerative Medicine Therapies

Criswell

Swart²,

Stoudemire

et al. 2022

Stem Cells Translational Medicine

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Advances in regenerative medicine manufacturing continue to be a priority for achieving the full commercial potential of important breakthrough therapies. Equally important will be the establishment of distribution chains that support the transport of live cells and engineered tissues and organs resulting from these advanced biomanufacturing processes. The importance of a well-managed distribution chain for products requiring specialized handling procedures was highlighted during the COVID-19 pandemic and serves as a reminder of the critical role of logistics and distribution in the success of breakthrough therapies. This perspective article will provide insight into current practices and future considerations for creating global distribution chains that facilitate the successful deployment of regenerative medicine therapies to the vast number of patients that would benefit from them worldwide.

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Cell therapy must be regulated as medicine

Cited by 4 publications

References 8 publications

Fluorescence intensity modulation of CdSe/ZnS quantum dots assesses reactive oxygen species during chemotherapy and radiotherapy for cancer cells

Fluorescence intensity modulation of CdSe/ZnS quantum dots assesses reactive oxygen species during chemotherapy and radiotherapy for cancer cells

Clinical trials of CAR-T cells in China

Shipping and Logistics Considerations for Regenerative Medicine Therapies

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