Cell therapy in female infertility-related diseases: Emphasis on recurrent miscarriage and repeated implantation failure

Pourakbari, Ramin; Ahmadi, Hamid; Yousefi, Mehdi; Aghebati‐Maleki, Leili

doi:10.1016/j.lfs.2020.118181

Cited by 43 publications

(27 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The therapeutic potential of MSCs stems from their ability to maintain homeostasis by migrating to the site of tissue injury and to promote tissue repair 4,5 . MSCs have shown great potential in the treatment of various models in vitro and in vivo of disease phenotypes including neurodegenerative and cardiovascular diseases, diabetes, acute kidney injury and female infertility 6‐10 …”

Section: Introductionmentioning

confidence: 99%

Adipose‐derived stem cells regulate metabolic homeostasis and delay aging by promoting mitophagy

Zhang

Jiang

et al. 2021

The FASEB Journal

View full text Add to dashboard Cite

Tissues undergo a process of degeneration as the body ages. Mesenchymal stem cells (MSCs) have been found to have major potential in delaying the aging process in tissues and organs. However, the mechanism underlying the anti‐aging effects of MSC is not clear which limits clinical applications. In this study, we used adipose‐derived mesenchymal stem cells (ADSCs) to perform anti‐aging treatments on senescent cells and progeroid animal models. Following intervention with ADSCs, replicative senescence was delayed and metabolic homeostasis was transformed from catabolism to anabolism. Metabolomic tests were used to analyze different metabolites. We found that ADSCs acted to accelerate mitophagy which eliminated intracellular ROS and improved the quality of mitochondria. These processes acted to regulate the cellular metabolic homeostasis and ultimately delayed the process of aging. Allogeneic stem cell therapy in a Progeria animal model (DNA polymerase gamma (POLG) knockin, mitochondrial dysfunction) also showed that ADSC therapy can improve alopecia and kyphosis by promoting mitophagy. Our research confirms for the first time that allogeneic stem cell therapy can improve aging‐related symbols and phenotypes through mitochondrial quality control. These results are highly significant for the future applications of stem cells in aging‐related diseases.

show abstract

Section: Introductionmentioning

confidence: 99%

Adipose‐derived stem cells regulate metabolic homeostasis and delay aging by promoting mitophagy

Zhang

Jiang

et al. 2021

The FASEB Journal

View full text Add to dashboard Cite

show abstract

“…They then were able to explore the most relevant miRNA in endometriosis [148][149][150]. This information is critical since directed therapies depending on endometriosis may provide new elements to control the inflammatory disease and aid in fertilization [148][149][150][151][152][153][154][155][156][157][158][159][160][161][162][163][164][165][166]. In addition, exosomes contain miRNA and other proteins.…”

Section: Exosomesmentioning

confidence: 99%

“…Other therapies involve platelet-rich plasma in the uterine cavity and the use of different stem cells [149][150][151][152][153][154][155]. The goal of the platelet-rich plasma is related to local TGFβ release and consequently promote NK differentiation [149][150][151][152][153][154][155]. There have not been conclusive studies using this therapy and other therapies involving various stem cells and allostimulation [155].…”

Section: Other Therapiesmentioning

confidence: 99%

A Brief Analysis of Tissue-Resident NK Cells in Pregnancy and Endometrial Diseases: The Importance of Pharmacologic Modulation

Garmendia

Sanctis

2021

Immuno

View full text Add to dashboard Cite

NK cells are lymphocytes involved in the innate and adaptative immune response. These cells are located in peripheral blood and tissues with ample functions, from immune vigilant to tolerogenic reactions. In the endometrium, NK cell populations vary depending on age, hormones, and inflammation. When pregnancy occurs, tissue-resident NK cells and conventional NK cells are recruited to protect the fetus, a tolerogenic response. On the contrary, in the inflamed endometrium, various inflammatory cells down-regulate NK tolerance and impair embryo implantation. Therefore, NK cells’ pharmacological modulation is difficult to achieve. Several strategies have been used, from progesterone, lipid emulsions to steroids; the success has not been as expected. However, new therapeutic approaches have been proposed to decrease the endometrial inflammatory burden and increase pregnancy success based on understanding NK cell physiology.

show abstract

“…Other strategies, such as various stem cell therapies, are not actually evaluated in the women with infertility. 81 The increasing evidence of link between microbiota and uterine immunity could also discuss this possible immunomodulation strategy in the future. 82…”

Section: Other Immunomodulatory Drugsmentioning

confidence: 99%

Endometriosis with infertility: A comprehensive review on the role of immune deregulation and immunomodulation therapy

Kolańska

Alijotas‐Reig

Cohen

et al. 2020

American J Rep Immunol

View full text Add to dashboard Cite

Background: Endometriosis is a multifactorial pathology dependent on intrinsic and extrinsic factors, but the immune deregulation seems to play a pivotal role. In endometriosis-associated infertility, this could raise the benefit of immunomodulatory strategies to improve the results of ART. In this review, we will describe (1) sera and peritoneal fluid cytokines and immune markers; (2) autoantibodies; and (3) immunomodulatory treatments in endometriosis with infertility.

show abstract

Cell therapy in female infertility-related diseases: Emphasis on recurrent miscarriage and repeated implantation failure

Cited by 43 publications

References 116 publications

Adipose‐derived stem cells regulate metabolic homeostasis and delay aging by promoting mitophagy

Adipose‐derived stem cells regulate metabolic homeostasis and delay aging by promoting mitophagy

A Brief Analysis of Tissue-Resident NK Cells in Pregnancy and Endometrial Diseases: The Importance of Pharmacologic Modulation

Endometriosis with infertility: A comprehensive review on the role of immune deregulation and immunomodulation therapy

Contact Info

Product

Resources

About