Cell therapy for destructive pancreatitis

Gasanova, S Yu

doi:10.17116/hirurgia202209150

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Autologous MSCs are considered safe and may be effective for certain conditions [ 92 ]. For example, the inclusion of MSCs in standard therapy for the early phase of acute severe pancreatitis in patients of the middle-aged group (approximately 44 years old) allows purposeful and relatively quick intervention in abnormal homeostatic processes, inhibiting toxic phenomena, restoring immune response, and improving microcirculation [ 93 ]. Positive results were obtained using bone marrow cells multiplied in vitro and injected into the defect site along with biphasic calcium phosphate granules, inducing the formation of new bone.…”

Section: Cell and Genetically Modified Cell-based Therapymentioning

confidence: 99%

Eternal Youth: A Comprehensive Exploration of Gene, Cellular, and Pharmacological Anti-Aging Strategies

Kitaeva,

Solovyeva,

Blatt

et al. 2024

IJMS

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The improvement of human living conditions has led to an increase in average life expectancy, creating a new social and medical problem—aging, which diminishes the overall quality of human life. The aging process of the body begins with the activation of effector signaling pathways of aging in cells, resulting in the loss of their normal functions and deleterious effects on the microenvironment. This, in turn, leads to chronic inflammation and similar transformations in neighboring cells. The cumulative retention of these senescent cells over a prolonged period results in the deterioration of tissues and organs, ultimately leading to a reduced quality of life and an elevated risk of mortality. Among the most promising methods for addressing aging and age-related illnesses are pharmacological, genetic, and cellular therapies. Elevating the activity of aging-suppressing genes, employing specific groups of native and genetically modified cells, and utilizing senolytic medications may offer the potential to delay aging and age-related ailments over the long term. This review explores strategies and advancements in the field of anti-aging therapies currently under investigation, with a particular emphasis on gene therapy involving adeno-associated vectors and cell-based therapeutic approaches.

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Section: Cell and Genetically Modified Cell-based Therapymentioning

confidence: 99%

Eternal Youth: A Comprehensive Exploration of Gene, Cellular, and Pharmacological Anti-Aging Strategies

Kitaeva,

Solovyeva,

Blatt

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Autologous MSCs are considered safe and may be effective for certain conditions [92]. For example, the inclusion of MSCs in the standard therapy for the early phase of acute severe pancreatitis in patients of the middle age group (approximately 44 years old) allows purposeful and relatively quick intervention in abnormal homeostatic processes, inhibiting toxic phenomena, restoring immune response, and improving microcirculation [93]. Positive results were obtained using bone marrow cells multiplied in vitro and injected into the defect site along with biphasic calcium phosphate granules, inducing the formation of new bone.…”

Section: Cell and Genetically Modified Cell-based Therapymentioning

confidence: 99%

Eternal Youth: A Comprehensive Exploration of Gene, Cellular, and Pharmacological Anti-aging Strategies

Kitaeva,

Solovyeva,

Blatt

et al. 2023

Preprint

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The enhancement of human living conditions has resulted in an increase in average life expectancy, giving rise to a novel social and medical challenge: aging, which diminishes the overall quality of human life. The aging process of the body begins through the activation of effector signaling pathways of aging in cells, loss of their normal functions and deleterious effects on the microenvironment, which leads to chronic inflammation and similar transformation of neighboring cells. The cumulative retention of these senescent cells over a prolonged period results in the deterioration of tissues and organs, ultimately leading to a reduced quality of life and an elevated mortality risk. Among the most encouraging methods for addressing aging and age-related illnesses are pharmacological, genetic, and cellular therapies. Elevating the activity of aging-suppressing genes, employing specific groups of native and genetically modified cells, and utilizing senolytic medications may offer the potential to delay aging and age-related ailments over the long term. The review explores the strategies and advancements in the field of anti-aging therapies that are currently under investigation, with a particular emphasis on gene therapy involving adeno-associated vectors and cell-based therapeutic approaches.

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Pathogenetic role of a number of factors in the development and progression of preeclampsia with varying severity in pregnant women

Ismailova,

Zame,

Akhmedzhanova

et al. 2024

Reprod. Fertil. Dev.

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Context Preeclampsia is a common pregnancy complication, posing significant risks to both the mother and fetus. Predicting and determining the risks of this disease is crucial. Aims This research aims to understand the pathogenetic role of several factors in the development and progression of preeclampsia, particularly in relation to its severity in pregnant patients. Methods The study included 60 pregnant women diagnosed with either mild or severe preeclampsia and 40 healthy pregnant women for comparison. Blood plasma was analysed using biochemical methods, and blood microcirculation parameters were determined to identify homeostatic abnormalities in early preeclampsia. Key results A molecular genetic study revealed the frequency of the endothelial nitric oxide gene eNOSC774T. Homeostatic abnormalities were statistically correlated with polymorphic genotypes of the eNOSC774T gene. Conclusions The research found a correlation between the T774T eNOS genotype mutation and the severity of preeclampsia, alongside significant homeostasis abnormalities in patients. Implications The T774T mutant genotype of the eNOS gene and higher levels of lipid peroxidation products are strongly linked to the severity and progression of preeclampsia. This highlights a significant connection between genetic predisposition and biochemical abnormalities in the disease’s development.

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Cell therapy for destructive pancreatitis

Cited by 3 publications

References 6 publications

Eternal Youth: A Comprehensive Exploration of Gene, Cellular, and Pharmacological Anti-Aging Strategies

Eternal Youth: A Comprehensive Exploration of Gene, Cellular, and Pharmacological Anti-Aging Strategies

Eternal Youth: A Comprehensive Exploration of Gene, Cellular, and Pharmacological Anti-aging Strategies

Pathogenetic role of a number of factors in the development and progression of preeclampsia with varying severity in pregnant women

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