Cell Therapy for Androgenetic Alopecia: Elixir or Trick?

Mao, Yongcui; Liu, Pinyan; Wei, Jiayun; Xie, Ye; Zheng, Qiang; Li, Rui; Yao, Jia

doi:10.1007/s12015-023-10532-2

Cited by 4 publications

(2 citation statements)

References 129 publications

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“…Its mechanism of action is based on the competitive inhibition of the cytoplasmic androgen receptors (AR) [69]. Some specialists may also perform stem cell-based therapies [70]. Mesenchymal stem cells derived from hair follicles and adipose tissue are currently being investigated [71,72].…”

Section: Ongoing Research -What May Be Broadly Used In the Futurementioning

confidence: 99%

The diagnosis and treatment of androgenetic alopecia: a review of the most current management

Śliwa,

Synia,

Placek

et al. 2023

Forum Dermatologicum

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Androgenetic alopecia is a widespread problem in contemporary dermatology, as it may also affect many young patients, in particular males, making them more prone to anxiety and depression which may be caused by a distorted body image. These behavioural problems may occur in older individuals as well. That is why, there is an obvious need for further development in that area of dermatology, which should also include discovering new therapies. In men, the diagnosis of androgenetic alopecia is quite simple, and the treatment usually involves incorporating minoxidil and/or finasteride. Switching from topical minoxidil to its systemic form as well as from finasteride to dutasteride may give better results in some patients. In general, male pattern hair loss (MPHL) is a chronic disease that may demand pharmacological treatment in the long term, which is often unlimited. Therefore, and also considering the patients' concerns involving the systemic usage of 5α-reductase inhibitors as well as the limitations of current therapies, some specialists use topical finasteride, dutasteride in mesotherapy and many other additional modalities. When it comes to female pattern hair loss (FPHL), in most cases it is also a chronic entity, which especially in younger women demands performing extended lab testing in the search for potential hyperandrogenism. It is necessary to remember that especially in women the condition may be triggered by many environmental and other additional factors, so taking that into consideration may be helpful in some patients.

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Section: Ongoing Research -What May Be Broadly Used In the Futurementioning

confidence: 99%

The diagnosis and treatment of androgenetic alopecia: a review of the most current management

Śliwa,

Synia,

Placek

et al. 2023

Forum Dermatologicum

View full text Add to dashboard Cite

show abstract

“…With the development of regenerative medicine, stem cell-based treatments have shown potential for hair regeneration and hair follicle repair as promising alternative. Stem cell therapy facilitates or orchestrates the growth, regeneration, and development of hair follicles by modulating pertinent signaling factors and pathways [ 23 ], including human follicle mesenchymal stem cells [ 24 ], mesenchymal stem cells (MSCs), and hair follicle stem cells (HFSCs) [ 25 , 26 ]. However, PRP therapy and stem cell therapy involve complex and cumbersome processes and are relatively expensive.…”

Section: Introductionmentioning

confidence: 99%

Hydrogel forming microneedles loaded with VEGF and Ritlecitinib/polyhydroxyalkanoates nanoparticles for mini-invasive androgenetic alopecia treatment

Ding,

Li,

Zhang

et al. 2024

Bioactive Materials

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Efficacy of Platelet-Rich Plasma versus Mesotherapy with Recombinant Growth Factors and Stem Cell-Conditioned Media in Androgenetic Alopecia: A Retrospective Study

Stefanis,

Arenberger,

Arenbergerova

et al. 2024

Skin Appendage Disord

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Introduction: Androgenetic alopecia (AGA) is the most common type of hair loss. Platelet-rich plasma (PRP) and mesotherapy (MZT) injections of various solutions fortified with growth factors are popular treatment options for AGA. The aim of this study was to compare the efficacy of RPP and MZT products in the treatment of AGA. Methods: This retrospective study included 72 AGA patients treated with two PRP formulations and two MZT products, administered manually or with a gun injector. Hair parameters (hair thickness, hair density, and hair count) on frontal and vertex areas were measured before and after 6 months. Results: Over 6 months, trichoscopic parameters showed significant intragroup and intergroup variability. MZT1 and PRP2 groups exhibited statistically significant improvement in most parameters, while MZT2 significantly increased vertex hair density. Hair thickness changes differed significantly between PRP1 and PRP2 groups (unadjusted p value <0.001) and possibly between MZT1 and PRP1 groups (unadjusted p value = 0.049) in both regions. Discussion: Injections of PRP and MZT formulations can significantly enhance trichoscopic parameters in AGA patients within a 6-month period, but the extent of improvement varies among different PRP and MZT products.

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Cell Therapy for Androgenetic Alopecia: Elixir or Trick?

Cited by 4 publications

References 129 publications

The diagnosis and treatment of androgenetic alopecia: a review of the most current management

The diagnosis and treatment of androgenetic alopecia: a review of the most current management

Hydrogel forming microneedles loaded with VEGF and Ritlecitinib/polyhydroxyalkanoates nanoparticles for mini-invasive androgenetic alopecia treatment

Efficacy of Platelet-Rich Plasma versus Mesotherapy with Recombinant Growth Factors and Stem Cell-Conditioned Media in Androgenetic Alopecia: A Retrospective Study

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