Cell therapy, 3D culture systems and tissue engineering for cardiac regeneration

Emmert, Maximilian Y.; Hitchcock, Robert W.; Hoerstrup, Simon P.

doi:10.1016/j.addr.2013.12.004

Cited by 91 publications

(66 citation statements)

References 208 publications

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“…CSCs/CPCs can be isolated from heart biopsies that are performed during interventional surgical procedures. They are defined by their multipotency and clonogenicity as well as by the presence of common stem cell markers, such as c-kit and Sca-1, and cardiac markers, such as Isl-1, Nkx2.5 and GATA4 [13]. Cells that migrate from cultured cardiac explants can form cardiospheres, which can then be dissociated to obtain cardiospherederived cells (CDCs) [14].…”

Section: Cardiac Stem and Progenitor Cellsmentioning

confidence: 99%

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Cardiac Regenerative Medicine: The Potential of a New Generation of Stem Cells

Cambria

Steiger

Günter

et al. 2016

Transfus Med Hemother

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Cardiac stem cell therapy holds great potential to prompt myocardial regeneration in patients with ischemic heart disease. The selection of the most suitable cell type is pivotal for its successful application. Various cell types, including crude bone marrow mononuclear cells, skeletal myoblast, and hematopoietic and endothelial progenitors, have already advanced into the clinical arena based on promising results from different experimental and preclinical studies. However, most of these so-called first-generation cell types have failed to fully emulate the promising preclinical data in clinical trials, resulting in heterogeneous outcomes and a critical lack of translation. Therefore, different next-generation cell types are currently under investigation for the treatment of the diseased myocardium. This review article provides an overview of current stem cell therapy concepts, including the application of cardiac stem (CSCs) and progenitor cells (CPCs) and lineage commitment via guided cardiopoiesis from multipotent cells such as mesenchymal stem cells (MSCs) or pluripotent cells such as embryonic and induced pluripotent stem cells. Furthermore, it introduces new strategies combining complementary cell types, such as MSCs and CSCs/CPCs, which can yield synergistic effects to boost cardiac regeneration.

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Section: Cardiac Stem and Progenitor Cellsmentioning

confidence: 99%

“…Although multipotent cells like MSCs possess a considerable potential for lineage specification, ESCs depict the gold standard for cardiomyocyte generation [13]. ESCs are blastocyst-derived cells that are pluripotent, meaning that they can differentiate into any cell type of the adult human body.…”

Section: Embryonic Stem Cells (Escs)mentioning

confidence: 99%

Cardiac Regenerative Medicine: The Potential of a New Generation of Stem Cells

Cambria

Steiger

Günter

et al. 2016

Transfus Med Hemother

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“…Based on an understanding of the pathogeneses of various CVDs, engineered cardiac tissue constructs can also serve as in vitro micro-physiological models for drug screening and disease detection [2,10–12]. Compared to the inconsistencies of two-dimensional (2D) cell-culture and animal models, the engineering of 3D microenvironments is better suited to replicate the substantial cell-cell and cell-matrix interactions of native human tissues [13,14]. The engineering of tissue for utility in cardiovascular regeneration is extremely challenging due to the inherent structural complexity of the associated in vivo tissue and as such, requires several considerations in the design process.…”

Section: Introductionmentioning

confidence: 99%

3D bioprinting for cardiovascular regeneration and pharmacology

Cui

Miao

Esworthy

et al. 2018

Advanced Drug Delivery Reviews

140

116

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Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide. Compared to traditional therapeutic strategies, three-dimensional (3D) bioprinting is one of the most advanced techniques for creating complicated cardiovascular implants with biomimetic features, which are capable of recapitulating both the native physiochemical and biomechanical characteristics of the cardiovascular system. The present review provides an overview of the cardiovascular system, as well as describes the principles of, and recent advances in, 3D bioprinting cardiovascular tissues and models. Moreover, this review will focus on the applications of 3D bioprinting technology in cardiovascular repair/regeneration and pharmacological modeling, further discussing current challenges and perspectives.

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“…The paradigm shift from 2D to 3D cell culture is already showing great benefit in basic research of tissues differentiation and homeostasis as well as in tissue engineering efforts for regenerative medicine applications. [1] Skeletal muscle and tendon tissues basically consist each of one single functional cell type: the multinucleated myotube and the tenocyte. Myotubes are the basic building block of skeletal muscle and are also called myofibers.…”

Section: Introductionmentioning

confidence: 99%