Cell-targeted, dual reduction- and pH-responsive saccharide/lipoic acid-modified poly(L-lysine) and poly(acrylic acid) polyionic complex nanogels for drug delivery

How, Su Chun; Chen, Yu Fon; Hsieh, Pin Lun; Wang, Steven S.‐S.; Jan, Jeng‐Shiung

doi:10.1016/j.colsurfb.2017.02.032

Cited by 36 publications

(12 citation statements)

References 45 publications

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“…As pH decreased further to 4.0, the zeta potentials of the NGs increased to ∼+3.8 and +2.0 mV, respectively. Since the degree of deprotonation for the carboxyl group reduced with the decrease of pH, NGs showed the positive charge (Supporting Information Figure S5). This conversion of zeta potential in NGs is similar to that seen in the polymeric micelles, presumably due to the structural resemblance of the polymers used .…”

Section: Resultsmentioning

confidence: 99%

“…Recently, poly(amino acid)‐based nanogels (NGs) such as poly( l ‐histidine)‐based NGs, poly( l ‐lysine)‐based NGs, and poly( l ‐aspartic acid)‐based NGs, poly( l ‐glutamic acid)‐ based NGs have been reported as novel smart nanocarriers with pH‐sensitive functionality. Chemical crosslinking among pH‐sensitive polymers is one method for manipulating the properties of the polymeric micelles .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development of pH‐sensitive nanogels for cancer treatment using crosslinked poly(aspartic acid‐graft‐imidazole)‐block‐poly(ethylene glycol)

Sim

Lim

Cho

et al. 2018

J of Applied Polymer Sci

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pH-sensitive nanogels (NGs) based on poly(aspartic acid-graft-imidazole)-poly(ethylene glycol) were developed using linear PEG with different molecular weights (2000 and 4000 Da) as crosslinkers. The pH-sensitive NGs showed reversible size changes during continuously alternating pH changes. The anticancer treatment potential of pH-sensitive NGs was studied using a model drug, irinotecan (IRI). IRI-loaded NGs (ILNs) showed different drug release kinetics in acidic versus neutral pH, in addition to pH-dependent cytotoxicity. Due to its longer crosslinker, ILN 4 (crosslinked with PEG 4000) showed faster IRI release and a greater magnitude of IRI release than ILN 2 (crosslinked with PEG 2000), resulting in greater cytotoxicity against HCT 116 colorectal cancer cells. These pH-sensitive NGs could potentially be used in cancer treatment by mediating the accumulation and release of IRI from ILNs in the acidic tumor environment and by reducing systemic toxicity due to reversible swelling-shrinkage.Recently, poly(amino acid)-based nanogels (NGs) such as poly (L-histidine)-based NGs, 23,24 poly(L-lysine)-based NGs, 25-31 and poly(L-aspartic acid)-based NGs, 32-35 poly(L-glutamic acid)-31,36-38 based NGs have been reported as novel smart nanocarriers with pHsensitive functionality. Chemical crosslinking among pH-sensitive polymers is one method for manipulating the properties of the polymeric micelles. 39,40 Poly(L-histidine)-based NGs showed selective drug release at low pH due to rapid shrinkage at extracellular or cytosolic pHs. Furthermore, endosomal physical disruption was achieved by the considerable volumetric expansion and proton sponge effect that occur at pH en . 41 Other NGs have also shown reversible swelling and drug release after alternating decreases and increases of pH (hereafter referred to as pH cyclization) 25,32 (Figure 1). This reversible swelling and shrinkage of NGs has been studied in the context of treating multidrug resistance tumors. 42 These NGs could release their drug payloads by NG swelling at the low pH of the tumor environment or in the endosomal compartment. After killing the cancer cells and Additional Supporting Information may be found in the online version of this article.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of pH‐sensitive nanogels for cancer treatment using crosslinked poly(aspartic acid‐graft‐imidazole)‐block‐poly(ethylene glycol)

Sim

Lim

Cho

et al. 2018

J of Applied Polymer Sci

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“…Here, we have examined, discussed, and reviewed the advances of polypeptide nanogels. In the drug‐delivery fields, polypeptide nanogels have been widely used due to their unique properties . As the field of drug delivery develops, different mono and multiresponsive nanogels are being explored for controlled drug delivery .…”

Section: Discussionmentioning

confidence: 99%

Advances in Stimuli‐Responsive Polypeptide Nanogels

et al. 2018

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Polymer nanogels, which are nanosized particles of hydrogels formed by physically or chemically crosslinking polymers, are one of the most promising nanoplatforms for use in biomedical applications, including drug delivery, gene therapy, and bioimaging. Polypeptide nanogels exhibit many advantages for applications in biomedical fields, including stable 3D structures, high drug‐loading efficiency, excellent biocompatibility, stimuli responsiveness, and so forth. More specifically, smart polypeptide nanogels undergo suitable transitions under endogenous (e.g., reduction, reactive oxygen species, pH, and enzymes) or exogenous stimuli (e.g., light, temperature, voltage, and magnetic fields) for on‐demand drug delivery. Here, a comprehensive introduction to the preparation and applications of diverse stimuli‐responsive polypeptide nanogels is given. Moreover, the opportunities and challenges of polypeptide nanogels for the development of biomedicine are briefly predicted.

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“…Dual stimuli‐responsive nanogels generally involve a combination of redox‐responsive cross‐linkers and pH‐responsive polymeric matrix as important nanogel constituents. Some of the important examples of pH‐responsive polymers are polyacrylamide (PAAm), poly(acrylic acid) (PAA), PMAA, poly(2‐diethylaminoethyl methacrylate) (PDEAEMA), polyethyleneimine, poly( l ‐lysine), poly(2‐vinyl pyridine) (P2VP), poly( N ‐vinylamine) (PVAm), poly(4‐vinyl pyridine) (P4VP), and chitosan . The pH‐ and redox‐responsive nanogels hold excellent potential and play a diverse role for targeted intracellular release of drugs due to their multidimensional role in response to variation in GSH concentration and pH inside the cellular compartment.…”

Section: Dual and Triple Stimuli‐responsive Nanogelsmentioning

confidence: 99%

A Comprehensive Outlook of Synthetic Strategies and Applications of Redox‐Responsive Nanogels in Drug Delivery

Kumar

Liu

Behl

2019

Macromolecular Bioscience

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Increasing recognition of the role of oxidative stress in the pathogenesis of many clinical conditions and the existence of defined redox potential in healthy tissues has led to extensive research in the development of redox‐responsive materials for biomedical applications. Especially, considerable growth has been seen in the fabrication of polymeric nanogel–based drug delivery carriers utilizing redox‐responsive cross‐linkers bearing a variety of functional groups via various synthetic strategies. Redox‐responsive polymeric nanogels provide an advantage of facile chemical modification post synthesis and exhibit a remarkable response to biological redox stimuli. Due to the interdisciplinary nature of the subject, a more profound combined conceptual knowledge from a chemical and biological point of view is imperative for the rational design of redox‐responsive nanogels. The present review provides an insight into the design and fabrication of redox‐responsive nanogels with particular emphasis on synthetic strategies utilized for the development of redox‐responsive cross‐linkers, polymerization techniques being followed for nanogel development and biomedical applications. Cooperative effect of redox trigger with other stimuli such as pH and temperature in the evolution of dual and triple stimuli‐responsive nanogels is also discussed.

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Cell-targeted, dual reduction- and pH-responsive saccharide/lipoic acid-modified poly(L-lysine) and poly(acrylic acid) polyionic complex nanogels for drug delivery

Cited by 36 publications

References 45 publications

Development of pH‐sensitive nanogels for cancer treatment using crosslinked poly(aspartic acid‐graft‐imidazole)‐block‐poly(ethylene glycol)

Development of pH‐sensitive nanogels for cancer treatment using crosslinked poly(aspartic acid‐graft‐imidazole)‐block‐poly(ethylene glycol)

Advances in Stimuli‐Responsive Polypeptide Nanogels

A Comprehensive Outlook of Synthetic Strategies and Applications of Redox‐Responsive Nanogels in Drug Delivery

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