Cell Survival, Death, and Proliferation in Senescent and Cancer Cells: the Role of (Poly)phenols

Sorrenti, Vincenzo; Buriani, Alessandro; Fortinguerra, Stefano; Davinelli, Sergio; Scapagnini, Giovanni; Cassidy, Aedín; Vivo, Immaculata De

doi:10.1016/j.advnut.2023.05.014

Cited by 7 publications

(2 citation statements)

References 252 publications

(308 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Phenolic compounds are plant secondary metabolites that are widely found in nature. Phenolic compounds are structurally diverse and have antioxidant, anti-tumor, and antiviral effects (Almanza-Aguilera et al 2023 ; Huminiecki 2022 ; Sorrenti et al 2023 ). Phenolic compounds can regulate cancer cell apoptosis by modulating protein kinases in the MAPK-signaling pathway.…”

Section: Natural Product-targeted Mapk-signaling Pathway For Cancer P...mentioning

confidence: 99%

Natural products targeting the MAPK-signaling pathway in cancer: overview

Shi,

Liu,

et al. 2024

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

Purpose This article summarizes natural products that target the MAPK-signaling pathway in cancer therapy. The classification, chemical structures, and anti-cancer mechanisms of these natural products are elucidated, and comprehensive information is provided on their potential use in cancer therapy. Methods Using the PubMed database, we searched for keywords, including “tumor”, “cancer”, “natural product”, “phytochemistry”, “plant chemical components”, and “MAPK-signaling pathway”. We also screened for compounds with well-defined structures that targeting the MAPK-signaling pathway and have anti-cancer effects. We used Kingdraw software and Adobe Photoshop software to draw the chemical compound structural diagrams. Results A total of 131 papers were searched, from which 85 compounds with well-defined structures were selected. These compounds have clear mechanisms for targeting cancer treatment and are mainly related to the MAPK-signaling pathway. Examples include eupatilin, carvacrol, oridonin, sophoridine, diosgenin, and juglone. These chemical components are classified as flavonoids, phenols, terpenoids, alkaloids, steroidal saponins, and quinones. Conclusions Certain MAPK pathway inhibitors have been used for clinical treatment. However, the clinical feedback has not been promising because of genomic instability, drug resistance, and side effects. Natural products have few side effects, good medicinal efficacy, a wide range of sources, individual heterogeneity of biological activity, and are capable of treating disease from multiple targets. These characteristics make natural products promising drugs for cancer treatment.

show abstract

Section: Natural Product-targeted Mapk-signaling Pathway For Cancer P...mentioning

confidence: 99%

Natural products targeting the MAPK-signaling pathway in cancer: overview

Shi,

Liu,

et al. 2024

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

show abstract

“…Once in the colon, some polyphenols undertake microbial fermentation producing small polyphenol bioactive metabolites, which, in part, might handle their health benefits [147]. Polyphenols' metabolic fate is thus affected by different factors, such as interindividual variations in polyphenol metabolism caused by genetic polymorphisms of transporters, metabolic enzymes, efflux pumps, and the bidirectional communication with the gut microbiota appears to be the primary driver of this interindividual difference [148][149][150].…”

Section: Polyphenols Bioavailability and Interaction With Microbiotamentioning

confidence: 99%

Diet and Aging: The Role of Polyphenol-Rich Diets in Slow Down the Shortening of Telomeres: A Review

D’Angelo

2023

Antioxidants

View full text Add to dashboard Cite

The ends of human chromosomes are defended by DNA–protein complexes named telomeres, which inhibit the chromosomes from fusing with each other and from being known as a double-strand break by DNA reparation proteins. Telomere length is a marker of biological aging, and disfunction of telomeres is related to age-related syndromes. Telomere attrition has been shown to be accelerated by oxidative stress and inflammation. Telomere length has been proven to be positively linked with nutritional status in human and animal scientific research as several nutrients influence it through mechanisms that imitate their function in cellular roles including oxidative stress and inflammation. Data reported in this article support the idea that following a low-in-fat and rich-plant polyphenols food diet seems to be able to slow down the shortening of telomeres.

show abstract