Cell surface peptidase CD26/DPPIV mediates G-CSF mobilization of mouse progenitor cells

Christopherson, Kent W.; Cooper, Scott; Broxmeyer, Hal E.

doi:10.1182/blood-2002-12-3893

Cited by 189 publications

(152 citation statements)

References 46 publications

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“…EMSA ERITIN contains beneficial natural compounds such as genistein, cytokinin, nicotinic acid, pantothenic acid, biotin, riboflavin, folic acid, thiamine, thymus, and brain [16], stromal cells [17], osteoblasts [18], immune cells, blood vessels, and heart. The main physiological function of the interaction SDF1/CXCR4 is set homing, storage, and defense of hematopoietic stem cells and progenitor cells that are still primitive [19]. From the obtained result, we found that EMSA ERITIN promote the production of pre-B-cell growth-stimulating factor, SDF-1, in bone marrow.…”

Section: Discussionsupporting

confidence: 53%

Polyherbal EMSA ERITIN Promotes Erythroid Lineages and Lymphocyte Migration in Irradiated Mice

2016

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Radiotherapy is commonly used to kill malignant cells, but it can significantly deplete hematopoietic and splenic erythroblasts. Radioprotective agents are therefore very important in clinical radiotherapy. We examined the effect of poly-herbal EMSA ERITIN on immunological responses when administered to sublethally irradiated mice with the aim of highlighting promotes erythroid lineages and lymphocytes migration in irradiated mice with the parameter are TER119+CD123+in bone marrow and SDF-1 in bone marrow and spleen organ. Normal BALB/c mice were sublethally irradiated with 600 rad. EMSA ERITIN was administered orally at different doses:(1.04, 3.125 and 9.375 mg/g body weight) for 15 days. On day 16 erythroid lineages (TER-119+CD123+) were observed in bone marrow and lymphocytes migration by the production of SDF-1 in spleen and bone marrow. Lymphocytes migration was indicated by the production of SDF-1 in spleen and bone marrow using flow cytometry analysis. EMSA ERITIN increased the generation of erythroid lineage cells marked by TER119+CD123+ and promoted lymphocyte migration by increasing SDF-1 production in bone marrow and spleen. EMSA ERITIN appears to be a powerful medicinal herb with potential as a food supplement to normalize homeostasis and erythropoiesis after radiation.

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Section: Discussionsupporting

confidence: 53%

Polyherbal EMSA ERITIN Promotes Erythroid Lineages and Lymphocyte Migration in Irradiated Mice

2016

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“…Mice lacking CD26 [54] and those treated with CD26 inhibitors, such as Diprotin A [55], demonstrated reduced progenitor cell mobilization, although definitive studies on transplantable HSC remain to be published. Furthermore, CD26 deficient mice still significantly mobilized progenitors in response to G-CSF, suggesting that other factors are involved in the process.…”

Section: Proteasesmentioning

confidence: 99%

Extracellular molecules in hematopoietic stem cell mobilisation

Bendall

2016

Int J Hematol

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“…For example, CD26 (DPP4, dipeptidylpeptidase 4) and carboxypeptidase M are proteases present on the surface HSPCs that can cleave CXCL12, thereby inhibiting CXCR4 signaling. 63,64 Pharmacologic or genetic inhibition of CD26 is associated with increased CXCR4 signaling and impaired G-CSF-induced HSPC mobilization. 65 Similarly, platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) is an adhesion molecule expressed on both stromal and hematopoietic cells.…”

Section: Cxcr4/cxcl12 Axismentioning

confidence: 99%