Cell surface expression of adhesins for fibronectin correlates with virulence in Sporothrix schenckii

Teixeira, Pedro A. C.; Castro, Rafaela Alves; Nascimento, Rosana Cícera; Tronchin, G.; Torres, Armando Pérez; Lazéra, Márcia; Almeida, Sandro Rogério de; Bouchara, Jean-Philippe; Penha, Carla V. Loureiro y; Lópes-Bezerra, Leila M.

doi:10.1099/mic.0.029439-0

Cited by 57 publications

(45 citation statements)

References 30 publications

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“…Some studies have demonstrated that the fungus has integrins or adhesin lectinlike molecules that recognize human fibronectin at several points on the molecule (135). The fibronectin adhesins are located on the surface of yeast cells, and their expression is related to fungal virulence (251). It is also known that these fibronectin receptors are different from laminin receptors (133).…”

Section: Adhesionmentioning

confidence: 99%

Sporothrix schenckii and Sporotrichosis

Barros

Paes²,

Schubach³

2011

Clin Microbiol Rev

519

677

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SUMMARY Sporotrichosis, which is caused by the dimorphic fungus Sporothrix schenckii , is currently distributed throughout the world, especially in tropical and subtropical zones. Infection generally occurs by traumatic inoculation of soil, plants, and organic matter contaminated with the fungus. Certain leisure and occupational activities, such as floriculture, agriculture, mining, and wood exploitation, are traditionally associated with the mycosis. Zoonotic transmission has been described in isolated cases or in small outbreaks. Since the end of the 1990s there has been an epidemic of sporotrichosis associated with transmission by cats in Rio de Janeiro, Brazil. More than 2,000 human cases and 3,000 animal cases have been reported. In humans, the lesions are usually restricted to the skin, subcutaneous cellular tissue, and adjacent lymphatic vessels. In cats, the disease can evolve with severe clinical manifestations and frequent systemic involvement. The gold standard for sporotrichosis diagnosis is culture. However, serological, histopathological, and molecular approaches have been recently adopted as auxiliary tools for the diagnosis of this mycotic infection. The first-choice treatment for both humans and cats is itraconazole.

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Section: Adhesionmentioning

confidence: 99%

Sporothrix schenckii and Sporotrichosis

Barros

Paes²,

Schubach³

2011

Clin Microbiol Rev

519

677

View full text Add to dashboard Cite

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“…Specific microbial adhesins mediate adherence to host tissues by participating in sophisticated interactions with some of the host proteins that compose the extracellular matrix (Teixeira et al, 2009). The adhesinencoding genes are not constitutively expressed.…”

Section: The Expression Of Adhesinsmentioning

confidence: 99%

Sporothrix schenckii complex biology: environment and fungal pathogenicity

et al. 2014

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Sporothrix schenckii is a complex of various species of fungus found in soils, plants, decaying vegetables and other outdoor environments. It is the aetiological agent of sporotrichosis in humans and several animals. Humans and animals can acquire the disease through traumatic inoculation of the fungus into subcutaneous tissue. Despite the importance of sporotrichosis, it being currently regarded as an emergent disease in several countries, the factors driving its increasing medical importance are still largely unknown. There have only been a few studies addressing the influence of the environment on the virulence of these pathogens. However, recent studies have demonstrated that adverse conditions in its natural habitats can trigger the expression of different virulence factors that confer survival advantages both in animal hosts and in the environment. In this review, we provide updates on the important advances in the understanding of the biology of Spor. schenckii and the modification of its virulence linked to demonstrated or putative environmental factors.

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“…Otra forma de medir la mortalidad que puede llegar a producir es su capacidad de unirse a la fibronectina vía las adhesinas de su superficie, un factor de virulencia que permite la invasión y diseminación a tejidos más profundos (20).…”

Section: Introductionunclassified

Esporotricosis y cromoblastomicosis: revisión de la literatura

Gaviria-Giraldo¹,

Cardona‐Castro²

2017

CES Med.

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ResumenLas micosis subcutáneas hacen referencia a infecciones producidas por hongos que se encuentran en la naturaleza, adquiridas por inoculación directa y limitadas a la dermis y tejido celular subcutáneo, pero pueden extenderse hacia la epidermis o hacia planos más profundos llegando a comprometer estructuras óseas, así como diseminarse y producir enfermedad sistémica. Dentro de las micosis subcutáneas más importantes en nuestro medio y de las cuales se hablarán en este artículo están la esporotricosis y la cromoblastomicosis; mientras que las menos frecuentes incluyen micetoma, quistes faeomicóticos, lacaziosis y la zigomicosis subcutánea.Palabras clave: Dermatomicosis, Esporotricosis, Cromoblastomicosis, Micosis subcutáneas. AbstractSubcutaneous mycoses, refer to infections caused by fungi which the ecologic niche is the nature, they are acquired by direct inoculation, limited to the dermis and subcutaneous tissue, but may extend into the epidermis or deeper levels reaching compromise bone structures and systemic spread and cause disease. Among the most important in our country, and which will discuss in this article, subcutaneous mycoses are sporotrichosis and chromoblastomycosis, mycetoma include less frequent, the faeomycosis, lacaziosis, and subcutaneous zygomycosis.Keywords: Dermatomycoses, Sporotrichosis, Chromoblastomycosis, Subcutaneous mycosis. IntroducciónLas infecciones micóticas incluyen un amplio grupo que van desde entidades superficiales hasta infecciones profundas asociadas a planos más profundos, que incluso llegan a comprometer estructuras óseas o diseminarse y producir enfermedad sistémica. Dentro de las micosis subcutáneas más importantes en nuestro medio están la esporotricosis y la cromoblastomicosis; las menos frecuentes son micetoma, quistes faeomicóticos, lacaziosis y zigomicosis subcutánea. Los microrganismos causantes se inoculan en la piel luego de un trauma con material vegetal contaminado con el hongo y por esto también han sido llamadas micosis de implantación (1,2).

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Cell surface expression of adhesins for fibronectin correlates with virulence in Sporothrix schenckii

Cited by 57 publications

References 30 publications

Sporothrix schenckii and Sporotrichosis

Sporothrix schenckii and Sporotrichosis

Sporothrix schenckii complex biology: environment and fungal pathogenicity

Esporotricosis y cromoblastomicosis: revisión de la literatura

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