Cell Surface Characteristics of Blastocysts from Spontaneously Ovulating and Gonadotropin-Treated Mice1

Champlin, Arthur K.; Kuzia, Stanley J.; Rice, Beverly A.; Mobraaten, Larry E.

doi:10.1095/biolreprod36.2.439

Cited by 13 publications

(7 citation statements)

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“…Other studies in agreement with our results presented here have demonstrated that the quality of embryos was affected by superovulation; for example Champlin AK et al [4] showed that blastocysts that developed in vivo in superovulated mice have fewer microvilli on their surface.…”

Section: Discussionsupporting

confidence: 93%

The Effect of Progesterone and Exogenous Gonadotropin on Preimplantation Mouse Embryo Development and Implantation

2008

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Section: Discussionsupporting

confidence: 93%

The Effect of Progesterone and Exogenous Gonadotropin on Preimplantation Mouse Embryo Development and Implantation

2008

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“…In vitro studies showed that ovarian stimulation disrupts (Ertzeid & Storeng 1992) Ertzeid & Storeng 2001). Furthermore, analysis of the surface architecture of mouse embryos showed a reduction in the number of cells and of microvilli on blastocysts from gonadotrophin-treated females, compared to those from spontaneously ovulating females (Champlin et al 1987). However, the results of human studies assessing possible effects of ovarian stimulation protocols on embryo development are inconsistent with mouse studies.…”

Section: How Does Ovarian Stimulation Affect Early Oocyte and Embryo mentioning

confidence: 99%

The impact of ovarian stimulation for IVF on the developing embryo

Santos¹,

Kuijk²,

Macklon³

2010

Reproduction

174

128

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The use of assisted reproductive technologies (ART) has been increasing over the past three decades, and, in developed countries, ART account for 1-3% of annual births. In an attempt to compensate for inefficiencies in IVF procedures, patients undergo ovarian stimulation using high doses of exogenous gonadotrophins to allow retrieval of multiple oocytes in a single cycle. Although ovarian stimulation has an important role in ART, it may also have detrimental effects on oogenesis, embryo quality, endometrial receptivity and perinatal outcomes. In this review, we consider the evidence for these effects and address possible underlying mechanisms. We conclude that such mechanisms are still poorly understood, and further knowledge is needed in order to increase the safety of ovarian stimulation and to reduce potential effects on embryo development and implantation, which will ultimately be translated into increased pregnancy rates and healthy offspring.

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“…However, there is increasing evidence suggesting that ovarian stimulation and the associated high estrogen levels are detrimental on the embryo and associated with a decrease in the fertilization rate. When compared with blastocysts derived from naturally cycling mice, blastocysts that developed in vivo in superovulated mice were found to have fewer microvilli on their surface [170], a reduced [ 35 S]-methionine uptake [171], and a lower cell number and mitotic index [172]. A reduced cell number and a two-fold decrease in viability post-transfer of embryos from gonadotropins-stimulated hamster females, was also observed [21].…”

Section: Part Onementioning

confidence: 99%

The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment

Mitwally

Casper

Diamond

2005

Reprod Biol Endocrinol

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Clinical utilization of ovulation stimulation to facilitate the ability of a couple to conceive has not only provided a valuable therapeutic approach, but has also yielded extensive information on the physiology of ovarian follicular recruitment, endometrial receptivity and early embryo competency. One of the consequences of the use of fertility enhancing agents for ovarian stimulation has been the creation of a hyperestrogenic state, which may influence each of these parameters. Use of aromatase inhibitors reduces hyperestrogenism inevitably attained during ovarian stimulation. In addition, the adjunct use of aromatase inhibitors during ovarian stimulation reduces amount of gonadotropins required for optimum stimulation. The unique approach of reducing hyperestrogenism, as well as lowering amount of gonadotropins without affecting the number of mature ovarian follicles is an exciting strategy that could result in improvement in the treatment outcome by ameliorating the deleterious effects of the ovarian stimulation on follicular development, endometrial receptivity, as well as oocyte and embryo quality. PART ONE IntroductionCurrent epidemiological evidence suggests that 15% of couples will experience infertility. Background prevalence rates now appear to be reasonably stable, but there is evidence of an increase in the rate of referrals for medical help [1,2]. Farley and Belsey, 1988 [3], have reported estimates of the prevalence (percentage) of primary infertility by region and country.

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Cell Surface Characteristics of Blastocysts from Spontaneously Ovulating and Gonadotropin-Treated Mice1

Cited by 13 publications

References 0 publications

The Effect of Progesterone and Exogenous Gonadotropin on Preimplantation Mouse Embryo Development and Implantation

The Effect of Progesterone and Exogenous Gonadotropin on Preimplantation Mouse Embryo Development and Implantation

The impact of ovarian stimulation for IVF on the developing embryo

The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment

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