Cell Surface Alterations in Transformed Tissue Culture Cells and their Possible Significance in Growth Control

The Plasma Unit Membrane.

“…Interestingly enough, after initial exposure to hormones and their specification on surface receptors, normal cells have been shown to be refractory to subsequent stimulation, but only for a short period of time (Newcombe et al, 1975). Moreover, the alteration of the cell surface and the loss of contact inhibition of growth induced by nonspecific treatment of normal cells with proteolytic enzymes was transient and reversible (Burger et al, 1972). In view of these findings it seems that transformed cells and possibly psoriatic keratinocytes are no more able to restore their surface properties spontaneously.…”

“…The 'loss of contact inhibition' was reversible by the addition of monovalent lectin, restoring cell surface architecture. These experiments provided evidence that the lectin-binding sites of the plasma unit membrane are related to growth control (Otten et al, 1971;Castor, 1972;Burger et al, 1972).…”

Membrandefekt als Basis der gestörten Wachstumsregulation bei Psoriasis

“…Denn es ist davon auszugehen, dass diese Impulse durch Substanzen der Zelloberfläche in das Zellinnere vermittelt werden [6,7], Wir haben daher mit verschiedenen Methoden den Aufbau der Zelloberflächen studiert (Tab. I).…”