Cell Subpopulations Overexpressing p75NTR Have Tumor-initiating Properties in the C6 Glioma Cell Line

Abstract

Cells with p75NTR overexpression demonstrated certain unique characteristics of tumor-initiating cells, such as neurosphere formation, high colony proliferation, and resistance to radio- and chemotherapy. With regard to the heterogeneous composition of glioma cells, p75NTR can be used as an alternative marker to identify a glioma subpopulation with tumor-initiating properties.

Bone Morphogenetic Protein 7 Effect on Human Glioblastoma Cell Transmigration and Migration

“…Previous studies from others and us have demonstrated the central regulator role of p75NTR in glioma migration and invasion, which transduces the glioma malignant signaling through nerve growth factor-p75NTR interaction and γ-secretase cleavage [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 31 ]. Moreover, it has been found that BMPs and p75NTR signaling might have cross-linking in regulating the neuron development, e.g., (i) BMP7 increases p75NTR expression to induce the dendritic growth of neuron [ 32 ] and (ii) BMP9 induces p75NTR expression in basal forebrain cholinergic neurons to regulate acetylcholine synthesis [ 33 ].…”

TMZ regulates GBM stemness via MMP14‐DLL4‐Notch3 pathway

“…Glioblastoma (GBM) recurrence after therapy is partially attributed to the activation of genetic programs supporting glioma stemness . By far, numerous mechanisms of glioma regrowth have been elucidated including expression of insulin like growth factor binding protein 6, p75NTR and SRY (sex determining region Y)‐box 9 . The same mechanisms are also implicated in glioma resistance as the transformed recurrent glioma cells become the driving force of GBM regrowth .…”