Cell Studies in Prolymphocytic Leukaemia

Singh, Amarendra K.; Vaughan-Smith, S.; Sawyer, B.; O'Connor, T. W. E.; Thomson, A. E. R.; Wetherley‐Mein, G.

doi:10.1111/j.1365-2141.1978.tb05835.x

Cited by 24 publications

(4 citation statements)

References 30 publications

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“…The endogenous origin and the independent identity of E-SRBC and SmIg in Case H were unequivocally established in a separate study and reported earlier (16). Similarly, in Case D, using the double marker technique (16), 33-38% of blood lymphocytes were shown to have formed E-SRBC and to bear SmIg (p and x chains).…”

Section: Omentioning

confidence: 53%

“…Bone marrow aspirate (approx 0.5 ml) obtained from the sternum or iliac crest was immediately mixed with 10 ml Hepes-buffered Tc199 (pH 7.4) containing heparin (10 U/ml) and subjected to density gradient separation (15,16).…”

Section: Methodsmentioning

confidence: 99%

“…Freshly separated lymphocytes (venous blood) and mononuclear cells (bone marrow) were examined for spontaneous rosette formation with sheep red cells (E-SRBC), complement (C3) binding sites (EAC rosettes), Fc receptors (EAy rosettes) and membrane surface immunoglobulins (SmIg). The methods for these investigations were modified from existing methods (17,18) and have been reported earlier (14,16).…”

Section: Methodsmentioning

confidence: 99%

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Heterogeneity of T‐Lymphocyte Chronic Lymphatic Leukaemia (CLL)

Singh

Lewis

Wetherley‐Mein

1984

Scandinavian Journal of Haematology

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Lymphocyte surface markers (E‐SRBC, EAC, EAγ and SmIg) and monoclonal antibodies (OKT3, OKT4, OKT8 and OKIa) were used to characterise the blood and bone marrow lymphocytes of T‐cell CLL (8 patients). The diagnosis of T‐cell CLL was made primarily as the majority of blood lymphocytes formed E‐SRBC in ecah patient. Other markers – EAC, EAγ and SmIg – showed different patterns of association with E‐SRBC. These findings considered together described 4 different phenotypes amongst these patients: (a) E+ (3 patients), (b) E+, EAC+ (1 patient), (c) E+, EAγ+ (2 patients), and (d) E+, SmIg+ (2 patients). Similarly, 4 different groups were defined with the help of monoclonal antibodies. Helper T‐cell (3 patients) and suppressor T‐cell (1 patient) CLL showed predominantly helper T‐ and suppressor T‐lymphocytes respectively. Mixed T‐cell CLL (1 patient) comprised an equal proportion of both subpopulations, while the remaining 3 patients, with excess of one or other subpopulations along with a considerable proportion of Ia antigen‐bearing lymphocytes, formed the indeterminate cell type CLL.

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Section: Omentioning

confidence: 53%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Heterogeneity of T‐Lymphocyte Chronic Lymphatic Leukaemia (CLL)

Singh

Lewis

Wetherley‐Mein

1984

Scandinavian Journal of Haematology

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“…The ultra~tructure,~.~ cytochem-istry6,7,9,10.1 1,13,14,16,17 and i m m u n~l o g i c~-~~~-'~~'~ fi ndings of T-cell PLL have been extensively described, but multiparametric immunologic studies using specific monoclonal antibodies in conjunction with postmortem examination have not been reported. This report presents the clinical, cytochemical, immunologic and ultrastructural findings of antemortem and postmortem tissue of a case of T-cell PLL with helper-cell phenotype in which extensive immunologic studies have been carried out, as well as a review of literature.…”

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confidence: 99%

T-cell prolymphocytic leukemia with helper-cell phenotype and a review of the literature

Tsai

Hyde

et al. 1984

Cancer

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The majority of published cases of prolymphocytic leukemia (PLL) have been of B‐cell origin. Nineteen cases of PLL of T‐cell type have been described, as has a single case of PLL having a surface phenotype with features of both B‐cells and T‐cells. This report presents a review of these cases and comparison with one case of T‐cell PLL. By using specific monoclonal antibody technique, this case was subcategorized into helper‐cell phenotype: E‐rosette(+), SIG(−), Anti‐T(+), Anti‐B(−), Anti‐monocyte(−), OKT3(+), OKT4(+), OKT6(−), OKT8(−), Ia(+), and Tdt(−). Cytochemical studies showed paranuclear acid phosphatase granules. Postmortem examination revealed a predominant T‐cell zone infiltration by the leukemic cells in the spleen and lymph nodes, with involvement of multiple organs. The application of the monoclonal antibody technique, which can be standardized among different laboratories to subclassify lymphoproliferative disorders into functional subtypes, should lead to a better understanding and more effective treatment of this disease.

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Prolymphocytic leukemia. Serial responses to therapy

Swift

Wold

Gandara

et al. 1984

Cancer

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Prolymphocytic leukemia is a rare lymphoproliferative disorder characterized by marked lymphocytosis, massive splenomegaly, minimal lymphadenopathy, and poor prognosis. Previous reports have noted very short survival, and poor response to single agent alkylator chemotherapy. A small number of reports have shown response to combination chemotherapy regimens including Adriamycin (doxorubicin). A case of prolymphocytic leukemia with serial responses to combination chemotherapy and splenectomy resulting in significant prolongation of survival is reported.

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Cell Studies in Prolymphocytic Leukaemia

Cited by 24 publications

References 30 publications

Heterogeneity of T‐Lymphocyte Chronic Lymphatic Leukaemia (CLL)

Heterogeneity of T‐Lymphocyte Chronic Lymphatic Leukaemia (CLL)

T-cell prolymphocytic leukemia with helper-cell phenotype and a review of the literature

Prolymphocytic leukemia. Serial responses to therapy

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