Cell state transition analysis reveals a causal network that controls critical limb ischemia
Oleksii S. Rukhlenko,
Joseph M. McClung,
Anna Tuliakova
et al.
Abstract:Increased endothelial cell (EC) permeability significantly contributes to peripheral arterial disease and its severe manifestation, critical limb ischemia (CLI). CLI remains refractory to current pharmacological interventions, often requiring limb amputation and showing how limited our knowledge is about signaling pathways that control EC states. Here, we utilize a two-pronged approach, employing cell State Transition Assessment and Regulation (cSTAR) analyses to both the published knowledge (e.g., LINCS data … Show more
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