Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak

Sovilj, Dana; Kelemen, Cristina Daniela; Dvorakova, Sarka; Zobalova, Renata; Raabova, Helena; Kriska, Jan; Hermanova, Zuzana; Knotek, Tomas; Anderova, Miroslava; Klener, Pavel; Filimonenko, Vlada; Neuzil, Jiri; Andera, Ladislav

doi:10.1007/s10495-023-01917-2

Apoptosis

2023

DOI: 10.1007/s10495-023-01917-2

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Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak

Dana Sovilj,

Cristina Daniela Kelemen,

Sarka Dvorakova

et al.

Abstract: We also acknowledge the BIOCEV European Regional Development Fund CZ.

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Humic Substances Suppresses the Proliferation of TC-1 Cells, the Lung Cancer Cell

Yang,

Chang

2023

Biomed Sci Letters

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In humic substances, fulvic acid (FA) is a subclass of diverse compounds known as humic substances, which are byproducts of organic degradation from microorganisms. FA can suppress the proliferation of tumor cells. Despite numerous studies, the exact mechanism for the various effects of FA is not clearly understood. Based on results demonstrating anti-proliferation effects on human cancer, we investigated whether FA has similar effects on lung cancer in this study. Firstly, the anti-cancer effect of FA in pulmonary epithelial tumor cell lines (TC-1 cells) was examined by confirming its inhibitory effect on the cell proliferation of TC-1 cells. TC-1 cell proliferation was reduced by FA on a dose-dependent and time-dependent manner. After 24 hours of FA treatment, cell morphological changes such as cell volume decrease, non-adherence and increased number of apoptotic cells were clearly observed. In addition, FA induced a DNA ladder pattern by increased of DNA fragments in TC-1 cells. In the intracellular regulatory pathway by FA, we confirmed that FA induced the reduction of the anti-apoptotic protein, Bcl-2 protein levels. These results indicate that FA has anticancer effect by inducing intracellular apoptotic pathway. Further research on the mechanism of anticancer effects will be basic data for the development of potential anticancer drugs.

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Humic Substances Suppresses the Proliferation of TC-1 Cells, the Lung Cancer Cell

Yang,

Chang

2023

Biomed Sci Letters

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Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak

Abstract: We also acknowledge the BIOCEV European Regional Development Fund CZ.

Cited by 1 publication

References 57 publications

Humic Substances Suppresses the Proliferation of TC-1 Cells, the Lung Cancer Cell

Humic Substances Suppresses the Proliferation of TC-1 Cells, the Lung Cancer Cell

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