Aptamers Selected by Cell-Selex for Theranostics 2015
DOI: 10.1007/978-3-662-46226-3_4
|View full text |Cite
|
Sign up to set email alerts
|

Cell-Specific Aptamer Characterization

Abstract: The functional diversity of cell-specific aptamers has enabled their use for a broad spectrum of biomedical applications. A thorough characterization of aptamers would provide better and deeper understanding and facilitate the development of customized aptamer-based diagnostics and therapeutics with enhanced performance. In this chapter, key properties of cell-specific aptamers and their characterization are discussed.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2022
2022
2022
2022

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(1 citation statement)
references
References 69 publications
0
1
0
Order By: Relevance
“…They display very high target specificity and superior binding affinity for the target molecule with dissociation constants from nano to picomolar range and other features that make them more appealing than antibodies [ 6 ]. Since first reported in the 1990s, several SELEX methods have been developed to facilitate more efficient isolation of aptamers for a wide variety of targets including ions [ 7 , 8 ], small molecules [ 9 ], proteins [ 10 ], and whole cells [ 11 ]. Graphene oxide-assisted SELEX (GO-SELEX) is an immobilization-free method that can be easily implemented to enrich the aptamer pool [ 12 , 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…They display very high target specificity and superior binding affinity for the target molecule with dissociation constants from nano to picomolar range and other features that make them more appealing than antibodies [ 6 ]. Since first reported in the 1990s, several SELEX methods have been developed to facilitate more efficient isolation of aptamers for a wide variety of targets including ions [ 7 , 8 ], small molecules [ 9 ], proteins [ 10 ], and whole cells [ 11 ]. Graphene oxide-assisted SELEX (GO-SELEX) is an immobilization-free method that can be easily implemented to enrich the aptamer pool [ 12 , 13 ].…”
Section: Introductionmentioning
confidence: 99%