Cell spatial analysis in Crohn's disease: unveiling local cell arrangement pattern with graph-based signatures
Shunxing Bao,
Sichen Zhu,
Vasantha L. Kolachala
et al.
Abstract:Crohn's disease (CD) is a chronic and relapsing inflammatory condition that affects segments of the gastrointestinal tract. CD activity is determined by histological findings, particularly the density of neutrophils observed on Hematoxylin and Eosin stains (H&E) imaging. However, understanding the broader morphometry and local cell arrangement beyond cell counting and tissue morphology remains challenging. To address this, we characterize six distinct cell types from H&E images and develop a novel approach for… Show more
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