Cell sorting by active forces in a phase-field model of cell monolayers

Graham, James N.; Zhang, Guanming; Yeomans, Julia M.

doi:10.1039/d3sm01033c

Soft Matter

2024

DOI: 10.1039/d3sm01033c

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Cell sorting by active forces in a phase-field model of cell monolayers

James N. Graham,

Guanming Zhang,

Julia M. Yeomans

Abstract: Cell sorting, the segregation of cells with different properties into distinct domains, is a key phenomenon in biological processes such as embryogenesis. We use a phase-field model of a confluent...

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Phase ordering in binary mixtures of active nematic fluids

Bhattacharyya,

Yeomans

2024

Phys. Rev. E

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We use a continuum, two-fluid approach to study a mixture of two active nematic fluids. Even in the absence of thermodynamically driven ordering, for mixtures of different activities we observe turbulent microphase separation, where domains form and disintegrate chaotically in an active turbulent background. This is a weak effect if there is no elastic nematic alignment between the two fluid components, but is greatly enhanced in the presence of an elastic alignment or substrate friction. We interpret the results in terms of relative flows between the two species which result from active anchoring at concentration gradients. Our results may have relevance in interpreting epithelial cell sorting and the dynamics of multispecies bacterial colonies. Published by the American Physical Society 2024

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Phase ordering in binary mixtures of active nematic fluids

Bhattacharyya,

Yeomans

2024

Phys. Rev. E

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Cell sorting by active forces in a phase-field model of cell monolayers

Abstract: Cell sorting, the segregation of cells with different properties into distinct domains, is a key phenomenon in biological processes such as embryogenesis. We use a phase-field model of a confluent...

Cited by 1 publication

References 39 publications

Phase ordering in binary mixtures of active nematic fluids

Phase ordering in binary mixtures of active nematic fluids

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