Cell size and geometry of spinal cord motoneurons in the adult cat following the intramuscular injection of adriamycin: comparison with data from aged cats

Liu, Rong-Huan; Yamuy, Jack; Engelhardt, John Kerch; Xi, Ming-Chu; Morales, Francisco R.; Chase, Michael H.

doi:10.1016/0006-8993(96)00769-x

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…In addition, changes in the first equalizing time constant ( c ) are also related to changes in membrane conductance (Rall, 1977;Yamuy et al, 1992b;Liu et al, 1996). The juxtacellular application of Hcrt-1 produced membrane depolarization and the discharge of lumbar spinal cord motoneurons.…”

Section: Time Constantsmentioning

confidence: 99%

Hypocretinergic Control of Spinal Cord Motoneurons

Yamuy

Fung²,

Xi³

et al. 2004

Journal of Neuroscience

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Hypocretinergic (orexinergic) neurons in the lateral hypothalamus project to motor columns in the lumbar spinal cord. Consequently, we sought to determine whether the hypocretinergic system modulates the electrical activity of motoneurons. Using in vivo intracellular recording techniques, we examined the response of spinal motoneurons in the cat to electrical stimulation of the lateral hypothalamus. In addition, we examined the membrane potential response to orthodromic stimulation and intracellular current injection before and after both hypothalamic stimulation and the juxtacellular application of hypocretin-1. It was found that (1) hypothalamic stimulation produced a complex sequence of depolarizing-hyperpolarizing potentials in spinal motoneurons; (2) the depolarizing potentials decreased in amplitude after the application of SB-334867, a hypocretin type 1 receptor antagonist; (3) the EPSP induced by dorsal root stimulation was not affected by the application of SB-334867; (4) subthreshold stimulation of dorsal roots and intracellular depolarizing current steps produced spike potentials when applied in concert to stimulation of the hypothalamus or after the local application of hypocretin-1; (5) the juxtacellular application of hypocretin-1 induced motoneuron depolarization and, frequently, high-frequency discharge; (6) hypocretin-1 produced a significant decrease in rheobase (36%), membrane time constant (16.4%), and the equalizing time constant (23.3%); (7) in a small number of motoneurons, hypocretin-1 produced an increase in the synaptic noise; and (8) the input resistance was not affected after hypocretin-1. The juxtacellular application of vehicle (saline) and denatured hypocretin-1 did not produce changes in the preceding electrophysiological properties.We conclude that hypothalamic hypocretinergic neurons are capable of modulating the activity of lumbar motoneurons through presynaptic and postsynaptic mechanisms. The lack of hypocretin-induced facilitation of motoneurons may be a critical component of the pathophysiology of cataplexy.

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Section: Time Constantsmentioning

confidence: 99%

Hypocretinergic Control of Spinal Cord Motoneurons

Yamuy

Fung²,

Xi³

et al. 2004

Journal of Neuroscience

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“…The input resistance of motor neurons also increases in old cats with no change in resting membrane potential or spike amplitude [6]. The increase in input resistance appears to depend upon both an increase in specific membrane resistance and a decrease in total cell surface area [7]. It is difficult or impossible to determine specific membrane resistance measurements in dendrites.…”

Section: Discussionmentioning

confidence: 99%

Physiological and Pharmacological Studies on Cervical Motor Neurons in Slices Prepared from Neonatal and Aged Mice

Hori¹,

Xu²,

Akaike³

et al. 2021

JBN

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The effects of age on the physiological properties of cervical motor neurons were examined in slices made from an excised spinal cord graft of ICR mice from the second day after birth to age 350 days. The membrane potential of post-natal day 2 (PD2) to PD350 was about -65 mV and did not change greatly with age, although it was slightly higher at PD2. However, there were significant changes in membrane resistance, which increased with age from about 15 to 30 MΩ. The depolarization induced by the excitatory amino acid agonists, kainic acid, NMDA and AMPA, decreased with aging in spite of the increase in membrane resistance. The motor neurons of the aged mice showed delayed recovery from excitation caused by excitatory amino acid agonists. By injecting Lucifer yellow CH into motor neurons, it was observed that the dendrite trees become thin, and some of the dendrite branches were missing in older animals.

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“…Input resistance can have a profound affect on cell excitability as the synaptic input sums in parallel with this resistance. In this regard, the apparent input resistance measured here is known to be attributable to neuronal size, degree o f innervation onto the soma, and the number o f ion channels, (Liu et al, 1996;Magee, 2000). As this parameter can have an effect on the efficacy o f synaptic responses (Magee, 2000), our results demonstrating that kindling significantly lowers this resistance in both Fast and Slow rats compared to sham controls suggests that cell excitability may be altered.…”

Section: Input Resistance Of Fast and Slow Ratsmentioning

confidence: 57%

A pharmacological examination of GABAb receptor-mediated inhibition in the amygdala of fast and slow kindling rat strains; in VIVO and in VITRO studies.

Shin¹

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Cell size and geometry of spinal cord motoneurons in the adult cat following the intramuscular injection of adriamycin: comparison with data from aged cats

Cited by 6 publications

References 38 publications

Hypocretinergic Control of Spinal Cord Motoneurons

Hypocretinergic Control of Spinal Cord Motoneurons

Physiological and Pharmacological Studies on Cervical Motor Neurons in Slices Prepared from Neonatal and Aged Mice

A pharmacological examination of GABAb receptor-mediated inhibition in the amygdala of fast and slow kindling rat strains; in VIVO and in VITRO studies.

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