Cell signalling pathway regulation by RanBPM: molecular insights and disease implications

Salemi, Louisa M.; Maitland, Matthew E. R.; McTavish, Christina J; Schild-Poulter, Caroline

doi:10.1098/rsob.170081

Cited by 35 publications

(68 citation statements)

References 142 publications

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“…IPO9 has been implicated in the regulation of a number of signaling pathways to regulate several cellular processes such as apoptosis, cell adhesion, migration, and transcription as well as plays a critical role during development. In addition, IPO9 has been shown to regulate pathways implicated in cancer and Alzheimer's disease, implying that IPO9 has important functions in both normal and pathological development . Interestingly, IPO9 possesses pro‐tumorigenic and tumor suppressive functions.…”

Section: Discussionmentioning

confidence: 99%

Differential Proteomic Analysis between Small Cell Lung Carcinoma (SCLC) and Pulmonary Carcinoid Tumors Reveals Molecular Signatures for Malignancy in Lung Cancer

Fujii

Miyata

Takahashi

et al. 2018

Proteomics Clinical Apps

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Section: Discussionmentioning

confidence: 99%

Differential Proteomic Analysis between Small Cell Lung Carcinoma (SCLC) and Pulmonary Carcinoid Tumors Reveals Molecular Signatures for Malignancy in Lung Cancer

Fujii

Miyata

Takahashi

et al. 2018

Proteomics Clinical Apps

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“…RanBPM is a 90‐kDa protein with a long stretch of Pro and Gln residues in its highly disordered N‐terminal region followed by conserved Sp1a kinase and ryanodine receptor (SPRY), lissencephaly type‐1‐like homology (LisH), C‐terminal to LisH (CTLH) and the C terminal CT‐11‐RanBPM (CRA) domains (Bai, Chen & Huang, ; Suresh, Ramakrishna & Baek, ; Salemi, Loureiro & Schild‐Poulter, ; Salemi et al, ). The interaction domain of p75 NTR with RanBPM was mapped to the p75 NTR ‐DD (Bai et al, ).…”

Section: P75ntr‐dd As An Intracellular Signalling Hubmentioning

confidence: 99%

Death domain of p75 neurotrophin receptor: a structural perspective on an intracellular signalling hub

2019

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The death domain (DD) is a globular protein motif with a signature feature of an all-helical Greek-key motif. It is a primary mediator of a variety of biological activities, including apoptosis, cell survival and cytoskeletal changes, which are related to many neurodegenerative diseases, neurotrauma, and cancers. DDs exist in a wide range of signalling proteins including p75 neurotrophin receptor (p75 NTR ), a member of the tumour necrosis factor receptor superfamily. The specific signalling mediated by p75 NTR in a given cell depends on the type of ligand engaging the extracellular domain and the recruitment of cytosolic interactors to the intracellular domain, especially the DD, of the receptor. In solution, the p75 NTR -DDs mainly form a symmetric non-covalent homodimer. In response to extracellular signals, conformational changes in the p75 NTR extracellular domain (ECD) propagate to the p75 NTR -DD through the disulfide-bonded transmembrane domain (TMD) and destabilize the p75 NTR -DD homodimer, leading to protomer separation and exposure of binding sites on the DD surface. In this review, we focus on recent advances in the study of the structural mechanism of p75 NTR -DD signalling through recruitment of diverse intracellular interactors for the regulation and control of diverse functional outputs.

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“…The few survivors are smaller in size compared to their littermates and completely lack spermatogenesis or oogenesis [18]. Of note, RANBP9 has been linked to different types of cellular stress and might work as part of macromolecular complexes [7].…”

Section: Known Biological Roles Of Ranbp9mentioning

confidence: 99%

Scorpins in the DNA Damage Response

Palmieri¹,

Tessari²,

Coppola³

2018

Preprint

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The DNA Damage Response (DDR) is a complex signaling network that comes into play when cells experience genotoxic stress. Upon DNA damage, cellular signaling pathways are rewired to slow down cell cycle progression and allow recovery. However, when the damage is beyond repair, cells activate complex and still not fully understood mechanisms, leading to a complete proliferative arrest or cell death. A number of conventional and novel anti-neoplastic treatments rely on causing DNA damage or on the inhibition of the DDR in cancer cells. However, the identification of molecular determinants directing cancer cells toward recovery or death upon DNA damage is still far from complete, and it is object of intense investigation. SPRY-COntaining RAN binding Proteins (Scorpins) RANBP9 and RANBP10 are evolutionarily conserved and ubiquitously expressed proteins whose biological functions are still debated. RANBP9 has been previously implicated in cell proliferation, survival, apoptosis and migration. Recent studies also showed that RANBP9 is involved in the Ataxia Telangiectasia Mutated (ATM) signaling upon DNA damage. Accordingly, cells lacking RANBP9 show increased sensitivity to genotoxic treatment. Although there is no published evidence, extensive protein similarities suggest that RANBP10 might have partially overlapping functions with RANBP9. Like RANBP9, RANBP10 bears sites putative target of PIK-kinases and high throughput studies found RANBP10 to be phosphorylated following genotoxic stress. Therefore, this second Scorpin might be another overlooked player of the DDR alone or in combination with RANBP9. This review focuses on the relatively unknown role played by RANBP9 and RANBP10 in responding to genotoxic stress.

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Cell signalling pathway regulation by RanBPM: molecular insights and disease implications

Cited by 35 publications

References 142 publications

Differential Proteomic Analysis between Small Cell Lung Carcinoma (SCLC) and Pulmonary Carcinoid Tumors Reveals Molecular Signatures for Malignancy in Lung Cancer

Differential Proteomic Analysis between Small Cell Lung Carcinoma (SCLC) and Pulmonary Carcinoid Tumors Reveals Molecular Signatures for Malignancy in Lung Cancer

Death domain of p75 neurotrophin receptor: a structural perspective on an intracellular signalling hub

Scorpins in the DNA Damage Response

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