Cell Repellent Coatings Developed by an Open Air Atmospheric Pressure Non-Equilibrium Argon Plasma Jet for Biomedical Applications

Abstract

A custom made non‐equilibrium atmospheric pressure argon plasma jet was developed for the deposition of PEG like coatings in open‐air for cell repellent applications. OES and electrical measurements were performed to characterize the discharge. The emission of the N2 (C3Πu–B3Πg) was followed in order to minimize the air entry in the plasma. Surface analyses were carried out on ap‐DEG coatings and the best retention of COC was obtained under mild plasma conditions. The ap‐DEG coatings were compared with typical LP deposited PEG like coatings. Less retention of COC and therefore less cell repellent properties were observed for ap‐DEG coatings as compared to those deposited at low pressure.

Deposition of Plasma‐Polymerized Polyacrylic Acid Coatings by a Non‐Equilibrium Atmospheric Pressure Nanopulsed Plasma Jet

“…The studies performed with this kind of sources demonstrated the effectiveness of non‐equilibrium APPJs in depositing polymeric films by means of monomer polymerization. For example, Bhatt et al pointed out the possibility to employ a non‐equilibrium Ar APPJ to deposit in open air PEG‐like coatings for cell repellent applications, while Vogelsang et al reported the first successful deposition of hydrophobic C:F thin film on conductive substrates with a RF capillary atmospheric pressure microplasma jet. With regard to AA plasma‐polymerization, Donegan and Dowling investigated the water stability, the chemical/morphological characteristics, and the level of protein adhesion of pPAA coatings deposited onto silicon substrates by using two different plasma jet deposition systems.…”

Energetics of reactions in a dielectric barrier discharge with argon carrier gas: VI PEG‐like coatings

“…83% using 4G aerosol; ca. 63% using 4G vapor), Da Ponte et al (65% using 4G aerosol), but comparable to Bhatt et al (56% using 2G vapor).…”

“…For example, vinyl‐containing compounds such as tri(ethylene glycol) divinyl ether, or di(ethylene glycol) vinyl ether were found to yield quite high PEG character in resulting PP. One of the above‐cited light oligoglymes, namely diglyme (2G) was used by Bhatt et al in AP PP experiments with an argon plasma jet; they reported partially‐reduced cell adhesion (human ovarian carcinoma cell line [NIH:OVCAR‐3]) on their coatings; those coatings possessed a PEG character of ca. 56%, below the accepted anti‐fouling threshold of ca.…”

Co‐Deposition of Plasma‐Polymerized Polyacrylic Acid and Silver Nanoparticles for the Production of Nanocomposite Coatings Using a Non‐Equilibrium Atmospheric Pressure Plasma Jet

“…The presence of nitrogen in the XPS survey spectrum can be probably appointed to the interaction of AA, or the products of its plasma-polymerization, with vibrationally excited N 2 molecules, resulting from the mixing of the plasma plume with the surrounding air, [43] as proposed by Bhatt et al [54] for the case of plasmapolymerization of diethylene glycol dimethyl ether; indeed, they observed by means of optical emission spectroscopy the formation of OH, CH, N 2 , and CN excited species when the monomer was introduced into the Ar plasma jet. The curve fitting of the high-resolution C 1s peak, shown in Figure 7, provides useful information on the retention of carboxyl groups in the chemical structure of the pPAA matrix of the nanocomposite coating.…”