Cell proliferation pattern in adult zebrafish forebrain is sexually dimorphic

Sexual dimorphisms in swimming behavior, cerebral metabolic activity and adrenoceptors in adult zebrafish (Danio rerio)

“…In support, α-ARs densities in rat hippocampus were also associated with gender related differences [29]. A plethora of evidences suggest that hippocampus, strongly linked with learning and memory processes, exhibit significant male -female differences in its neuroanatomical and neurochemical organization [48,69,70,71]. A very intriguing role of sex dimorphisms in mammalian hippocampus is related to the reaction to chronic stress [70,71], that is suggested to cause severe damages into male hippocampus but does not affect the female one [72].…”

“…SRY) or discernible sex chromosomes. It is an important model for understanding neuronal mechanisms underlying gender related plasticity events, as it displays sexual dimorphisms in social behavior [43], locomotion [44], preference space for shoaling [45], in brain gene expression [46], and cell proliferation rates in both cerebellum [47] and forebrain [48]. Furthermore, zebrafish, exhibit clear behavioral anxiety responses evoked by unfamiliar environment including reduced exploration, increased freezing behavior and erratic movements, which are quantifiable using either manual registration or computeraided video-tracking analyses [49,50].…”

Steroid modulation of neurogenesis: Focus on radial glial cells in zebrafish

“…When male and female were compared, no obvious differences were found in the ventral telencephalon, in the preoptic area and in the ventromedian hypothalamus [17]. However, more recent data showed that the dorsal telencephalon and the thalamus exhibited higher level of proliferating cells in females while in the dorsal part of the hypothalamus the quantity of cycling cells is higher in males [99]. Our data clearly shown for the first time that some of the dividing cells along the ventricles correspond to AroB-RGCs, which demonstrate that in fish as in mammals, RGCs are capable to generate new cells and display progenitor properties (Fig.…”

Early life low intensity stress experience modifies acute stress effects on juvenile brain cell proliferation of European sea bass ( D. Labrax )

“…In contrast to mammals, teleost brain is characterized by extensive adult neurogenesis [25][26][27][28], providing an excellent model for adult brain plasticity.…”