Cell proliferation marker MCM2, but not Ki67, is helpful for distinguishing between minimally invasive follicular carcinoma and follicular adenoma of the thyroid

Mar, Kwei; Eimoto, Tadaaki; Nagaya, Sachiko; Tateyama, Hisashi

doi:10.1111/j.1365-2559.2006.02430.x

Cited by 26 publications

(9 citation statements)

References 30 publications

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“…In the case of well differentiated tumors, lower, but overlapping, values between groups were noted in our study. No significant difference in MIB-1 index between follicular tumors (FTA, atypical FTA, FTC) was observed, in agreement with some studies from immunohistochemical studies (9,21). Nevertheless, significant differences in MIB-1 index between benign and malignant follicular tumors have been presented by others (19,22,23).…”

Section: Discussionsupporting

confidence: 80%

“…MIB-1 proliferation index, has been studied in many types of tumors and is commonly found to be of significant prognostic value (8). In thyroid specimens, several immunohistochemistry studies have suggested that MIB-1 index has no additive diagnostic value (9,10). However, we recently carried out a study on 30 PTC patients by evaluating their clinical follow-up and post-operative MIB-1 index.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic and prognostic potential of MIB-1 proliferation index in thyroid fine needle aspiration biopsy

Sofiadis

Tani²,

Foukakis³

et al. 2009

Int J Oncol

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Abstract. Fine needle aspiration biopsy (FNAB) is the preferred technique for the initial diagnostic evaluation of thyroid lesions, which nevertheless poses a diagnostic challenge for all clinicians involved. The latter necessitates the use of molecular markers on thyroid cytology. MIB-1 is a molecular marker already used in the cytological evaluation of various tumors. In this study, we assessed whether MIB-1 proliferation index adds diagnostic information to the conventional cytological analysis of thyroid nodules and prognostic information in thyroid cancers. MIB-1 index for various thyroid lesions was retrospectively reviewed in a series of 504 patients. Furthermore, the prognostic value of MIB-1 index was investigated for 183 of the patients with papillary thyroid cancer (PTC). MIB-1 index was significantly higher in anaplastic thyroid cancer (ATC) compared to other tumor types (p<0.01). No significant difference in MIB-1 index was observed between thyroid adenomas and follicular carcinomas. In PTC, MIB-1 index equal to or >4% was found to be an independent factor significantly associated with higher risk of distant metastasis and disease-related mortality (p<0.05). Conclusively, this study shows that preoperative MIB-1 index assessment in FNAB of thyroid nodules offers little diagnostic information as far as follicular tumors are concerned. In cases of PTC, though, MIB-1 may serve as a prognostic indicator of disease spreading and poor survival and hence influence the planning of the overall treatment scheme.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Diagnostic and prognostic potential of MIB-1 proliferation index in thyroid fine needle aspiration biopsy

Sofiadis

Tani²,

Foukakis³

et al. 2009

Int J Oncol

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“…Reports of these genes were also seen in related studies of EC in China and overseas [16][17][18][19] . The functions of these genes are mainly involved in DNA replication, transcription regulation, enzymatic reactions, and the roles in cell differentiation, movement, adhesion and anti-apoptosis, etc [20][21][22][23] . Further studies on the functions of these genes in development and invasion by the EC are expected.…”

Section: Discussionmentioning

confidence: 99%

Studies of differentially-expressed genes in human endometrial cancer of various differentiated grades

Cai

Hogg

et al. 2007

Chin. J. Clin. Oncol.

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“…Sir : Several markers have been tried to help to differentiate prognostically relevant subgroups of follicular thyroid neoplasms; one of the latest was recently published in Histopathology 1 . This paper highlights the proliferation profiles (differences in MCM2 and Ki67 expression) and the topographical distribution of these markers in follicular thyroid neoplasms diagnosed by World Health Organization criteria 2 .…”

Section: Ki67 and Isel Indices By Topographical Compartments In Follmentioning

confidence: 99%

“…The immunoexpression was scored on the basis of positive nuclei staining homogeneously for MCM2 or Ki67 and assessing tumour cells in the peripheral and central part of each tumour. The authors reported no correlation between MCM2 and Ki67 (Spearman's correlation coefficient r = 0.149) and MCM2 expression predominated in peripheral tumour cells in most of the minimally invasive follicular thyroid carcinomas (FTC), whereas it was diffuse with no apparent topographical differences in many follicular thyroid adenomas (FTA) 1 …”

Section: Ki67 and Isel Indices By Topographical Compartments In Follmentioning

confidence: 99%

Kinetic topographical heterogeneity in follicular thyroid neoplasms and growth patterns

Díaz‐Cano¹

2007

Histopathology

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OFD or a metaphyseal fibrous defect ⁄ non-ossifying fibroma-the most likely diagnoses for tumour sited in the cortical bone. A haematoxylin and eosin-stained section of the needle core biopsy specimen showed the characteristic features of a chondroblastoma, despite the fact that the vast majority of chondroblastomas are intramedullary epiphyseal neoplasms. Many of the lesional cells were strongly and diffusely positive for CKs (extensively positive for MNF116, AE1 ⁄ AE3, CAM5.2, CK8 and CK18 and more focally positive for CK19) (Figure 2).Another diagnosis that should be considered in a case of an unusual CK+ skeletal neoplasm is an extraaxial chordoma ⁄ chordoma periphericum, a neoplasm which also expresses CKs, specifically CK19. 6 However, our CK+ intracortical neoplasm was negative for brachyury, a transcription factor which is crucial for notochordal development. We have recently found this molecule to be expressed in 100% of 52 axial chordomas analysed and not in over 300 other tumours apart from one intracortical tibial neoplasm. 2,3 This brachyury-positive extra-axial neoplasm exhibited characteristic, although not typical, morphology and typical immunohistochemistry (CK19, S100 and brachyury) of a chordoma. However, as it was not sited in the spinal column, we propose that it is more appropriate to classify such a neoplasm as one showing notochordal differentiation rather than a chordoma. Chordomas are considered to arise from notochordal remnants and it is unlikely that ectopic notochordal remnants account for the origin of this tumour.

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Cell proliferation marker MCM2, but not Ki67, is helpful for distinguishing between minimally invasive follicular carcinoma and follicular adenoma of the thyroid

Abstract: MCM2, but not Ki67, is a helpful marker for differentiating MIFC from FA. The tumour cell proliferative activity supports the histological criteria based on diagnosing MIFC by either capsular or vascular invasion only.

Cited by 26 publications

References 30 publications

Diagnostic and prognostic potential of MIB-1 proliferation index in thyroid fine needle aspiration biopsy

Diagnostic and prognostic potential of MIB-1 proliferation index in thyroid fine needle aspiration biopsy

Studies of differentially-expressed genes in human endometrial cancer of various differentiated grades

Kinetic topographical heterogeneity in follicular thyroid neoplasms and growth patterns

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