Cell proliferation in ventromedial hypothalamic lesioned rats inhibits acute gastric mucosal lesions

Ishizuka, Noriko; Imazeki, Nobuo; Senoo, Akira; Sakurai, Junko; Sonoda, Masaru; Kanazawa, Masao; Suzuki, Yoko; Kobayashi, Yôko; Takahashi, T.; Haba, Ryota; Arai, Katsumi; Shimizu, Hiroyuki; Sasaki, Kahoru; Kako, Masako; Hayashi, Kaori; Suzuki, Yuichi; Inoue, Shuji

doi:10.1016/j.orcp.2011.12.003

Cited by 2 publications

(6 citation statements)

References 28 publications

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“…Acid secretion stimulated by 2-DG or insulin is not significantly different between VMH-lesioned rats and control rats 25 . Recent studies demonstrated that gastric acid secretion was nearly three times higher at baseline in VMH-lesioned rats compared to sham VMH-lesioned rats after pentagastrin stimulation 24 . To study the role of the VMH in the genesis of stress-induced gastric mucosal injury, we detected the effect of electrolytic lesions of the VMH on gastric acid secretion and gastric mucosal damage index in rats during water-immersion restraint stress.…”

Section: Discussionmentioning

confidence: 99%

“…Damage to the ventromedial hypothalamus causes an increase in gastric acid secretion 23 , 24 . However, the effects of RWIS on gastric acid secretion in VMH-lesioned rats remain unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Convergent evidence has shown that VMH lesions caused increased mitotic index, thickness of the gastric mucosal cell layer and hypersecretion of gastric acid 24 . Gastric vagotomy restored these parameters to normal.…”

Section: Discussionmentioning

confidence: 99%

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Ventromedial hypothalamic nucleus in regulation of stress-induced gastric mucosal injury in rats

Sun

Zhao

Liu

et al. 2018

Sci Rep

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Previous studies showed that restraint water-immersion stress (RWIS) increases the expression of Fos protein in the ventromedial hypothalamic nucleus (VMH), indicating the VMH involving in the stress-induced gastric mucosal injury (SGMI). The present study was designed to investigate its possible neuro-regulatory mechanisms in rats receiving either VMH lesions or sham surgery. The model for SGMI was developed by restraint and water (21 ± 1 °C) immersion for 2 h. Gastric mucosal injury index, gastric motility, gastric acid secretion and Fos expression in the hypothalamus and brainstem were examined on the 15th postoperative day in RWIS rats. Gastric mucosal injury in VMH-lesioned rats was obviously aggravated compared to the control. Gastric acidity under RWIS was obviously higher in VMH-lesioned rats than that in sham rats. Meantime, the VMH-lesioned rats exhibited marked increases in the amplitude of gastric motility in the VMH lesions group after RWIS. In VMH-lesioned rats, Fos expression significantly increased in the dorsal motor nucleus of the vagus (DMV), the nucleus of the solitary tract (NTS), the area postrema (AP), the paraventricular nucleus (PVN) and the supraoptic nucleus (SON) in response to RWIS. These results indicate that VMH lesions can aggravate the stress-induced gastric mucosal injury through the VMH-dorsal vagal complex (DVC)-vagal nerve pathway.

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Section: Discussionmentioning

confidence: 99%

“…Damage to the ventromedial hypothalamus causes an increase in gastric acid secretion 23 , 24 . However, the effects of RWIS on gastric acid secretion in VMH-lesioned rats remain unclear.…”

Section: Discussionmentioning

confidence: 99%

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Ventromedial hypothalamic nucleus in regulation of stress-induced gastric mucosal injury in rats

Sun

Zhao

Liu

et al. 2018

Sci Rep

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“…Ishizuka y colaboradores [29] sugieren que el control de las secreciones ácidas son meca fundamentales en la prevención de ulceras gástricas, de manera que estos resultados permiten sugerir otro eventual mecanismo de gastroprotección para el EALp. En conjunto con el aumento en el volumen gástrico, es sensato sugerir un efecto secretor básico por parte del EALp, el cual apoyaría la actividad observada en los biomodelos mencionados anteriormente.…”

Section: Ealp Sobre La Motilidad Intestinal (A) Y Sobre El Vaciamientunclassified

“…Este extracto aumentó significativamente el volumen de fluidos gástricos, al mismo tiempo que disminuyó la acidez de dicho contenido. Este comportamiento se diferencia al control tratado con RAN, en el cual la disminución no se ve acompañada con aumento de contenido Ishizuka y colaboradores [29] sugieren que el control de las secreciones ácidas son mecanismos fundamentales en la prevención de ulceras gástricas, de manera que estos resultados permiten sugerir otro eventual mecanismo de gastroprotección para el EALp. En conjunto con el aumento en el volumen gástrico, es sensato sugerir ásico por parte del EALp, el cual apoyaría la actividad observada en los biomodelos mencionados anteriormente.…”

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Efecto del extracto acuoso de hojas de <i>Licania platypus (Hemsl.) Fritsh</i>. Sobre la protección gástrica y la motilidad gastrointestinal.

Aguilar¹,

Rojas²,

Flores³

et al. 2018

Rev Med UCR

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Licania platypus se distribuye ampliamente en países tropicales. Tradicionalmente, en América Central se ha utilizado para diversos problemas de salud, especialmente gastrointestinales. Objetivo: Investigar la actividad antiulcerosa gástrica y el efecto sobre la motilidad gastrointestinal del extracto acuoso de hojas de Licania platypus. Métodos: El daño gástrico fue inducido con los modelos de etanol e indometacina y se evaluaron otros parámetros en el modelo de ligadura pilórica. Además, se analizó el efecto sobre la motilidad gastrointestinal utilizando rojo de fenol. Resultados: La administración oral del extracto acuosos (1000mg/kg) redujo significativamente el área de las lesiones gástricas (p<0,05) en ambos modelos. Se observó un incremento en el volumen de las secreciones gástricas y en la secreción de moco gástrico, además de una disminución en la acidez total y en la peroxidación lipídica (p<0,05). El extracto acuoso de Licania platypus brinda un efecto gastroprotector en diferentes modelos de inducción de úlceras agudas y una disminución en el vaciamiento gástrico. Las actividades demostradas en este estudio contribuyen con el conocimiento etnofarmacológico atribuido a Licania platypus.

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Cell proliferation in ventromedial hypothalamic lesioned rats inhibits acute gastric mucosal lesions

Cited by 2 publications

References 28 publications

Ventromedial hypothalamic nucleus in regulation of stress-induced gastric mucosal injury in rats

Ventromedial hypothalamic nucleus in regulation of stress-induced gastric mucosal injury in rats

Efecto del extracto acuoso de hojas de <i>Licania platypus (Hemsl.) Fritsh</i>. Sobre la protección gástrica y la motilidad gastrointestinal.

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