Cell Proliferation in the Dentate Gyrus of Rat Hippocampus Is Inhibited by Soft Diet Feeding

Aoki, Hiromichi; Kimoto, Katsuhiko; Hori, Norio; Toyoda, Minoru

doi:10.1159/000088700

Cited by 57 publications

(40 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, food texture also has an impact on AHN; rats fed with a soft diet, as opposed to a solid/hard diet, exhibit decreased hippocampal progenitor cell proliferation. The authors hypothesize that chewing resulting in cell proliferation is related to corticosterone levels [4]. Interestingly, independent studies have shown impairment in learning and memory abilities with similar soft diets [59,114].…”

Section: Dietary Modulation Of Adult Hippocampal Neurogenesismentioning

confidence: 99%

Impact of diet on adult hippocampal neurogenesis

2009

View full text Add to dashboard Cite

Research over the last 5 years has firmly established that learning and memory abilities, as well as mood, can be influenced by diet, although the mechanisms by which diet modulates mental health are not well understood. One of the brain structures associated with learning and memory, as well as mood, is the hippocampus. Interestingly, the hippocampus is one of the two structures in the adult brain where the formation of newborn neurons, or neurogenesis, persists. The level of neurogenesis in the adult hippocampus has been linked directly to cognition and mood. Therefore, modulation of adult hippocampal neurogenesis (AHN) by diet emerges as a possible mechanism by which nutrition impacts on mental health. In this study, we give an overview of the mechanisms and functional implications of AHN and summarize recent findings regarding the modulation of AHN by diet.

show abstract

Section: Dietary Modulation Of Adult Hippocampal Neurogenesismentioning

confidence: 99%

Impact of diet on adult hippocampal neurogenesis

2009

View full text Add to dashboard Cite

show abstract

“…Animal Model Intervention Outcome [10] Wistar rats Soft diet Cell proliferation in the dentate gyrus is suppressed by soft diet feeding [19] C57BL/6 mice Soft diet Soft diet mice showed behavioural impairments, such as decreased home cage activity, increased open field test activity, and deficits in prepulse inhibition, but no impairments in memory and learning. Decreased cell proliferation in the hippocampus, BDNF and Akt1 (protein kinase B) gene expression [36] C57BL/6 mice Hard diet Improved spatial learning ability of hard diet mice.…”

Section: Referencementioning

confidence: 99%

“…Experimental studies discussed, mainly done on mice, have consistently shown that impairing masticatory function results in both cellular and behavioural changes. A recurring theme identified is that of a decrease in neural stem cells proliferation in the hippocampus in many of the animal studies, when masticatory impairment was simulated by feeding mice a soft/powdered/liquid diet [10,19,33,34].…”

Section: Outcome Of Rodent Studiesmentioning

confidence: 99%

“…The loss of teeth has also been suggested to be related to the development of senile dementia and Alzheimer's disease [9], with both conditions featuring loss of memory function and disturbed learning, areas that AHN has been hypothesised to modulate [4]. Several studies have investigated whether masticatory impairment affects AHN in mice and rat models, such as through soft-diet feeding (not requiring mastication) [10] and removal of molars [11] with another study demonstrating that a soft-diet in mice after weaning resulted in impaired AHN in later life [12]. A review of the relationship between mastication and dementia surmised that a correlation does indeed exist [13].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The impact of mastication on cognition: Evidence for intervention and the role of adult hippocampal neurogenesis

Smith

Miquel-Kergoat²,

Thuret

2016

NUA

View full text Add to dashboard Cite

Abstract. Adult hippocampal neurogenesis (AHN) in the dentate gyrus of the hippocampus has been shown to affect mood, cognition, learning ability and memory. A growing area of interest is whether mastication or chewing also affects AHN. This article aims to collect the evidence from animal and human studies to ascertain whether mastication is an oral environment enrichment capable of having a modulatory effect on AHN and associated behaviors.Current data point toward a causal relationship between masticatory ability and cognitive function. Experimental studies on mice and rats have consistently shown that impairing masticatory function results in physical and behavioral changes. A recurring theme of decreased neural stem cells proliferation in the hippocampus was seen in most of the studies found. Human population study has shown that tooth loss and masticatory difficulty are positively correlated with having greater odds of cognitive impairment. However, no causal mechanism has yet been found to explain the effects of mastication on AHN.Further studies, especially in humans, are warranted to ascertain whether mastication could be used as a potential health intervention to slowdown cognitive decline in the aging population or delay the onset of diseases such as dementia.

show abstract

“…20 Aoki et al 21 reported that feeding a soft diet inhibited cell proliferation in the dentate gyrus of the rat hippocampus. Kimoto et al 22 conducted a morphological study in rats and proved that tooth loss caused not only receptor loss but also neuro-nal death in the mesencephalic nucleus of the trigeminal nerve.…”

Section: Changes In Body Weightmentioning

confidence: 99%

Hippocampal Glutamate Release on Learning and Memory in Teeth-loss Rats

Matsuno

Inoue

2008

Prosthodont Res. Pract.

View full text Add to dashboard Cite

The present study investigated the effects of tooth loss on learning and memory in rats by measuring hippocampal glutamate levels during a passive-avoidance task. The results clarified that tooth loss may be one of the factors inpending learning and memory; this is significant in the field of prosthodontics. AbstractPurpose: To clarify the effects of molar tooth loss on learning and memory, hippocampal glutamate release during a passive-avoidance task was measured with a telemetric glutamate biosensor. Methods: Male Sprague-Dawley rats were used. Under general anesthesia, all the maxillary molars were extracted from the EXT group rats (n = 8); those in the CON group (control, n = 8) were anesthetized without tooth extraction. At age 7 weeks, the rats were subjected to a passive-avoidance task consisting of acquisition and retention trials. Simultaneously, hippocampal glutamate release was measured. First, during the acquisition trial, the rats were placed in a light compartment, and the duration before they entered a dark compartment was measured (reaction latency). Immediately after the rat entered the dark compartment, an electric shock was applied through a grid floor. After 24 h, the retention trial was performed, and the reaction latency was measured in the same manner. Further, a biosensor was used to measure the release of hippocampal glutamate before and after the start of each trial. Results: Regarding the reaction latency during the passive-avoidance task, no significant differences were seen between the groups in the acquisition trial. Reaction latency increased in both groups in the retention trial, but was significantly shorter in the EXT group. Furthermore, hippocampal glutamate release in the acquisition trial was significantly shorter in the EXT group, but in the retention trial, no significant difference in glutamate release was seen between the groups. Conclusion: Molar tooth loss may impede learning and memory.

show abstract

Cell Proliferation in the Dentate Gyrus of Rat Hippocampus Is Inhibited by Soft Diet Feeding

Cited by 57 publications

References 55 publications

Impact of diet on adult hippocampal neurogenesis

Impact of diet on adult hippocampal neurogenesis

The impact of mastication on cognition: Evidence for intervention and the role of adult hippocampal neurogenesis

Hippocampal Glutamate Release on Learning and Memory in Teeth-loss Rats

Contact Info

Product

Resources

About