Cell Proliferation and Apoptosis in Human Middle Ear Cholesteatoma

Abstract

Proliferation in cholesteatoma epidermal cells is not uncontrolled, as it is in malignant tumors. Our results demonstrate an increase in the rate of proliferation and apoptotic cell death in cholesteatoma epidermis.

Marcadores de hiperproliferação na epiderme do meato acústico externo

“…They showed that there is a gradual reduction of its expression on the tympanic membrane in a centripetal direction, similar to the CK16. Kojima et al 13 and Tanaka et al 14 also found positiveness …”

“…As to study designs, 14 (87.5%) were cross-sectional [1][2][3][4][5][6][7][8][9][10][11][12][13][14] and only two (12.5%) were experimental 15,16 . Among all the papers included in this review, five (31.25%) were published with the only goal of analyzing, by means of immunohistochemistry, the epidermis of the normal external auditory meatus 1,4,5,8,16 .…”

“…Among all the papers included in this review, five (31.25%) were published with the only goal of analyzing, by means of immunohistochemistry, the epidermis of the normal external auditory meatus 1,4,5,8,16 . The other 11 studies (68.75%) were used only as control sample to assess the immunoexpression of cholesteatoma antigens, of the middle or external ear 2,7,8,[10][11][12][13][14][15][16] . Many markers were studied by means of the immunohistochemical methods in the investigations analyzed.…”

Taraxerol exerts potent anticancer effects via induction of apoptosis and inhibition of Nf-kB signalling pathway in human middle ear epithelial cholesteatoma cells

“…The aetiology of this pathological condition is not well understood [1,2]. Moreover, the current treatments are not satisfactory, and are associated with side-effects [3].…”

“…The reasons for the extension into the middle ear and aetiology of cholesteatotoma are yet to be fully understood [1]. However, it is believed that the epithelium proliferates due to some growth stimulus, leading to chronic inflammation [2]. A few studies reported the involvement of infections in the onset of cholesteatoma.…”