Cell-printed hierarchical scaffolds consisting of micro-sized polycaprolactone (PCL) and electrospun PCL nanofibers/cell-laden alginate struts for tissue regeneration

Yeo, MyungGu; Kim, GeunHyung

doi:10.1039/c3tb21163k

Cited by 67 publications

(65 citation statements)

References 37 publications

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“…In addition to their capability to fabricate complex structures with high precision, various studies have also shown their capability to construct scaffolds laden with cells and GFs. Currently most studies on RP and AM process have focused on PCL based scaffolds [337, 338], but with superior properties and their dynamic nature, we can anticipate significant progress in PLA based biomaterials [339] for osteochondral regeneration. This is particular true with evolution of FEA models to predict the mechanical and cell behavior of the constructs, especially a complicated one such as those for osteochondral regeneration.…”

Section: Cartilage Regenerationmentioning

confidence: 99%

Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

Narayanan

Vernekar

Kuyinu

et al. 2016

Advanced Drug Delivery Reviews

376

240

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Regenerative engineering converges tissue engineering, advanced materials science, stem cell science, and developmental biology to regenerate complex tissues such as whole limbs. Regenerative engineering scaffolds provide mechanical support and nanoscale control over architecture, topography, and biochemical cues to influence cellular outcome. In this regard, poly (lactic acid) (PLA)-based biomaterials may be considered as a gold standard for many orthopaedic regenerative engineering applications because of their versatility in fabrication, biodegradability, and compatibility with biomolecules and cells. Here we discuss recent developments in PLA-based biomaterials with respect to processability and current applications in the clinical and research settings for bone, ligament, meniscus, and cartilage regeneration.

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Section: Cartilage Regenerationmentioning

confidence: 99%

Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

Narayanan

Vernekar

Kuyinu

et al. 2016

Advanced Drug Delivery Reviews

376

240

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“…With exception of extracellular derived compounds or moieties that not always are obtained from cost-effective sources, those constructs frequently lack cell instructive cues. (Silva, et al, 2010) To improve cell behavior on such structures, usually the scaffolds are prepared combining different top-down techniques (Wang, et al, 2011b;Yeo and Kim, 2014) or are subjected to further functionalization requiring integrative approaches (Macdonald, et al, 2011;Yeo and Kim, 2011;Oliveira, et al, 2013c). For instance, electrospinning and 3D printing can be combined to prepare hierarchical scaffolds with dual scale fibers: the printed micro-struts combined with electrospun nano/microfibers.…”

Section: Top-down Approachmentioning

confidence: 99%

Towards the design of 3D multiscale instructive tissue engineering constructs: Current approaches and trends

Oliveira

Reis

Mano

2015

Biotechnology Advances

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The design of 3D constructs with adequate properties to instruct and guide cells both in vitro and in vivo is one of the major focuses of tissue engineering. Successful tissue regeneration depends on the favorable crosstalk between the supporting structure, the cells and the host tissue so that a balanced matrix production and degradation are achieved. Herein, the major occurring events and players in normal and regenerative tissue are overviewed. These have been inspiring the selection or synthesis of instructive cues to include into the 3D constructs. We further highlight the importance of a multiscale perception of the range of features that can be included on the biomimetic structures. Lastly, we focus on the current and developing tissue-engineering approaches for the preparation of such 3D constructs: top-down, bottom-up and integrative. Bottom-up and integrative approaches present a higher potential for the design of tissue engineering devices with multiscale features and higher biochemical control than top-down strategies, and are the main focus of this review.

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“…This issue has been addressed by Yeo et al, who developed a novel cell-laden hydrogel-based hierarchical scaffold produced by assembling micro-sized PCL struts, with both electrospun PCL nanofibers and cell-laden alginate struts to induce continuous cell release and promote cell migration, proliferation and ECM synthesis [61,62].…”

Section: Multi-feature Integration At the Fabrication Levelmentioning

confidence: 99%