Cell primitive-based biomimetic nanomaterials for Alzheimer's disease targeting and therapy

Yin, Tong; Liu, Yan; He, Bin; Gong, Baofeng; Chu, Jianjian; Gao, Chao; Liang, Wendanqi; Hao, Mengqi; Sun, Wenjing; Zhuang, Jianhua; Gao, Jie; Yin, You

doi:10.1016/j.mtbio.2023.100789

Cited by 2 publications

(2 citation statements)

References 161 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…188 Under conditions such as brain inflammation, chemokines like CCL19 or CCL20 play a pivotal role in recruiting immune cells, including macrophages, to the affected area. 189 MM-NPs, equipped with macrophage membranes, are drawn to these chemotactic signals and can efficiently home in on the inflamed brain regions. 190 The study by Han, Yang et al explores a novel approach to improve drug delivery and therapeutic outcomes in AD using specialized nanocarriers.…”

Section: Viral Inspired Approachmentioning

confidence: 99%

“…These nanoparticles are enveloped by membranes derived from macrophages, effectively mimicking the surface properties of these immune cells . Under conditions such as brain inflammation, chemokines like CCL19 or CCL20 play a pivotal role in recruiting immune cells, including macrophages, to the affected area . MM-NPs, equipped with macrophage membranes, are drawn to these chemotactic signals and can efficiently home in on the inflamed brain regions …”

Section: Biomimetic Approaches For Cns Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Bioinspired Approaches for Central Nervous System Targeted Gene Delivery

Kumar,

Karim,

Sweety

et al. 2023

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Disorders of the central nervous system (CNS) which include a wide range of neurodegenerative and neurological conditions have become a serious global issue. The presence of CNS barriers poses a significant challenge to the progress of designing effective therapeutic delivery systems, limiting the effectiveness of drugs, genes, and other therapeutic agents. Natural nanocarriers present in biological systems have inspired researchers to design unique delivery systems through biomimicry. As natural resource derived delivery systems are more biocompatible, current research has been focused on the development of delivery systems inspired by bacteria, viruses, fungi, and mammalian cells. Despite their structural potential and extensive physiological function, making them an excellent choice for biomaterial engineering, the delivery of nucleic acids remains challenging due to their instability in biological systems. Similarly, the efficient delivery of genetic material within the tissues of interest remains a hurdle due to a lack of selectivity and targeting ability. Considering that gene therapies are the holy grail for intervention in diseases, including neurodegenerative disorders such as Alzheimer's disease, Parkinson's Disease, and Huntington's disease, this review centers around recent advances in bioinspired approaches to gene delivery for the prevention of CNS disorders.

show abstract

Section: Viral Inspired Approachmentioning

confidence: 99%

Section: Biomimetic Approaches For Cns Diseasesmentioning

confidence: 99%

Bioinspired Approaches for Central Nervous System Targeted Gene Delivery

Kumar,

Karim,

Sweety

et al. 2023

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

show abstract

BNIP1 inhibits the fusion of autophagosome and lysosome in hippocampal neurons and promotes the development of Alzheimer's disease

Li,

Zhang,

Xia

et al. 2024

Preprint

View full text Add to dashboard Cite

Background BNIP1 (BCL2 interacting protein 1) is a soluble N-ethyl maleimide sensitive factor attachment protein receptor, and its decreased expression is potentially associated with the occurrence and development of Alzheimer's disease (AD), and the regulation of BNIP1 has potential significance for the prevention and treatment of AD. Methods The expression of BNIP1 protein was detected in APP/PS1 transgenic mice and APP-overexpressed HT22 hippocampal nerve cells. The most relevant protein components of BNIP1 expression were investigated by mass spectrometry. After using small interfering RNA and plasmid to regulate the expression of BNIP1, the detection results were strengthened to ensure the accuracy and reliability of the experiment. Results In our study, we detected that the decrease of BNIP1 protein in APP/PS1 double-transgenic mice and APP-overexpressed HT22 hippocampal nerve cells inhibited the fusion of autophagosome and lysosome, and further induced the decrease of Rab7 protein in Rab5b recruitment. Overexpression of BNIP1 can promote the fusion of autophagosome and lysosome. The knockdown of BNIP1 resulted in further dysfunction of autophagosome and lysosome fusion of APP-overexpressed HT22 hippocampal nerve cells. Conclusions These results suggest that the decrease of BNIP1 can lead to the dysfusion of AD autophagosome and lysosome, while overexpression of BNIP1 can ultimately promote the fusion of AD autophagosome and lysosome by inducing Rab5b to recruit Rab7, which provides a potential intervention target for the treatment of AD.

show abstract

Cell primitive-based biomimetic nanomaterials for Alzheimer's disease targeting and therapy

Cited by 2 publications

References 161 publications

Bioinspired Approaches for Central Nervous System Targeted Gene Delivery

Bioinspired Approaches for Central Nervous System Targeted Gene Delivery

BNIP1 inhibits the fusion of autophagosome and lysosome in hippocampal neurons and promotes the development of Alzheimer's disease

Contact Info

Product

Resources

About