Cell polarity signaling in the regulation of syncytiotrophoblast homeostasis and inflammatory response

Shaha, Sumaiyah; Patel, Khushali; Riddell, Meghan

doi:10.1016/j.placenta.2022.11.007

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Pe Pregnancy1

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2024

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Cited by 2 publications

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“…However, under the influence of persistent inflammation during pregnancy, there is a transition to the M1 phenotype, which may be based on an increase in NFκB expression [47]. Syncytiotrophoblast dysfunction is a key feature in PE, reports have observed disruption of syncytiotrophoblast apical microvilli, indicating a loss of apical polarity, which can be disrupted by pro-inflammation [48].…”

Section: Pe Pregnancymentioning

confidence: 99%

The NFκB Signaling Pathway Is Involved in the Pathophysiological Process of Preeclampsia

Li,

Zhu,

et al. 2024

Geburtshilfe Frauenheilkd

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The high prevalence of preeclampsia (PE) is a major cause of maternal and fetal mortality and affects the long-term prognosis of both mother and baby. Termination of pregnancy is currently the only effective treatment for PE, so there is an urgent need for research into its pathogenesis and the development of new therapeutic approaches. The NFκB family of transcription factors has an essential role in inflammation and innate immunity. In this review, we summarize the role of NFκB in normal and preeclampsia pregnancies, the role of NFκB in existing treatment strategies, and potential NFκB treatment strategies.

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Section: Pe Pregnancymentioning

confidence: 99%