Cell-Molecular Interactions of Nano- and Microparticles in Dental Implantology

Labis, Varvara; Bazikyan, E. A.; Demin, D. E.; Dyachkova, I. G.; Золотов, Д. А.; Волков, А. В.; Асадчиков, В. Е.; Жигалина, О. М.; Хмеленин, Д. Н.; Kuptsova, Daria; Петричук, С. В.; Семикина, Е. Л.; Сизова, С. В.; Oleinikov, Vladimir; Хайдуков, С. В.; Kozlov, Ivan

doi:10.3390/ijms24032267

Cited by 4 publications

(6 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…182 Other recent research with soft tissue biopsies from orthopedic and dental implants concluded that nanoscale metallic particles play a role both in physiological and pathophysiological reactions of the immune system and may participate in osseointegration and disintegration of dental implants. 183 When the amount of particles crosses a threshold called "Critical Dose of Nanoscale Metallic Particles," a local intensification of inflammation is observed, with early death of immune cells and failed removal of debris, leading to further accumulation of nanoparticles and chronic inflammation. The authors claimed that mucositis and peri-implantitis could be related to the accumulation of metal nanoparticles in the bone bed as a precipitant factor for aseptic inflammation with an autoimmune component.…”

Section: Findings From In Vivo Oral Biopsiesmentioning

confidence: 99%

“…The authors also recommended delayed dental implantation to achieve successful long-term osseointegration instead of immediate loading so that the immune system could to eliminate the metallic particles accumulated during the insertion before loading and before microbial contamination. 183…”

Section: Findings From In Vivo Oral Biopsiesmentioning

confidence: 99%

“…The authors remarked the need to analyze cross‐contamination in metal particle detection tests 182 . Other recent research with soft tissue biopsies from orthopedic and dental implants concluded that nanoscale metallic particles play a role both in physiological and pathophysiological reactions of the immune system and may participate in osseointegration and disintegration of dental implants 183 . When the amount of particles crosses a threshold called “Critical Dose of Nanoscale Metallic Particles,” a local intensification of inflammation is observed, with early death of immune cells and failed removal of debris, leading to further accumulation of nanoparticles and chronic inflammation.…”

Section: Implant‐related Factors Altering Bone Metabolismmentioning

confidence: 99%

“…Moreover, clinical manifestations of mucositis might be related to microparticle accumulation due to mechanical loading and delayed cleaning of antigenic particles. The authors also recommended delayed dental implantation to achieve successful long‐term osseointegration instead of immediate loading so that the immune system could to eliminate the metallic particles accumulated during the insertion before loading and before microbial contamination 183 …”

Section: Implant‐related Factors Altering Bone Metabolismmentioning

confidence: 99%

See 3 more Smart Citations

Emerging factors affecting peri‐implant bone metabolism

Insua,

Galindo‐Moreno,

Miron

et al. 2023

Periodontology 2000

View full text Add to dashboard Cite

Implant dentistry has evolved to the point that standard implant osseointegration is predictable. This is attributed in part to the advancements in material sciences that have led toward improvements in implant surface technology and characteristics. Nonetheless, there remain several cases where implant therapy fails (specifically at early time points), most commonly attributed to factors affecting bone metabolism. Among these patients, smokers are known to have impaired bone metabolism and thus be subject to higher risks of early implant failure and/or late complications related to the stability of the peri‐implant bone and mucosal tissues. Notably, however, emerging data have unveiled other critical factors affecting osseointegration, namely, those related to the metabolism of bone tissues. The aim of this review is to shed light on the effects of implant‐related factors, like implant surface or titanium particle release; surgical‐related factors, like osseodensification or implanted biomaterials; various drugs, like selective serotonin reuptake inhibitors, proton pump inhibitors, anti‐hypertensives, nonsteroidal anti‐inflammatory medication, and statins, and host‐related factors, like smoking, diet, and metabolic syndrome on bone metabolism, and aseptic peri‐implant bone loss. Despite the infectious nature of peri‐implant biological complications, these factors must be surveyed for the effective prevention and management of peri‐implantitis.

show abstract

Section: Findings From In Vivo Oral Biopsiesmentioning

confidence: 99%

Section: Findings From In Vivo Oral Biopsiesmentioning

confidence: 99%

Section: Implant‐related Factors Altering Bone Metabolismmentioning

confidence: 99%

Section: Implant‐related Factors Altering Bone Metabolismmentioning

confidence: 99%

See 2 more Smart Citations

Emerging factors affecting peri‐implant bone metabolism

Insua,

Galindo‐Moreno,

Miron

et al. 2023

Periodontology 2000

View full text Add to dashboard Cite

show abstract

“…[4]. One of the reasons for the development of such complications is probably the release of nanoparticles of the oxide layer of the dental implant in the tissue of the bone bed [2,7]. The accumulation and conglomeration of such particles, as well as their biocorrosion, can probably be a personalized cause of the development of mucositis and peri-implantitis, which is associated with the inability of the cells of the immune system to timely utilize these particles, preventing their conglomeration, and their early death.…”

Section: Introductionmentioning

confidence: 99%

Microscopic and elemental analysis of jaw bone tissue in injury

et al. 2023

View full text Add to dashboard Cite

Since the jawbone tissue is injured at the stage of metal dental implant introduction, the problem of inflammatory complication development leading to a breakdown in osseointegration remains relevant. Of interest are the immunological mechanisms of inflammatory process development during the emission of metal nanoparticles, as well as the mechanisms of its subsidence after the removal of a metal object. Microscopic and elemental analysis of the bone tissue of the Wistar rat lower jaw after artificial traumatization was carried out. During the experiment, the situation of presence of a metal foreign body in the bone bed was simulated. An insulin needle was injected into the connective tissue of the lower jaw, followed by its removal after seven days. Microscopic analysis of bone tissue was performed using a Tesscan Vega 4 scanning electron microscope. The teeth alveoli cortical layer surface, connection of the jaws with a gap, stratification of the cartilaginous layer were determined at low magnification in direct projection. Using higher magnification in the direct projection there are visible dense-structural crystalline inclusions, foci of necrosis in the area of junctions of the jaws alveolar processes. The elemental composition of bone tissue was obtained by atomic emission spectroscopy by iCAP 6300 Duo. In the test sample, the quantitative ratio of calcium and phosphorus was 1.68, which slightly exceeds the optimal value of 1.67. An upward change in this ratio indicates a decrease in phosphorus level, which can be interpreted as local osteoporosis. In addition, the following elements were found: Bi, Ga, Pb, Ti, Zn in the amount of 0.03-0.06 mass percent. The list of these elements corresponds to the chemical composition of an insulin needle, indicating the penetration of metal particles into bone bed tissues. The emission of nanoparticles and their subsequent association to micro- and submicron sizes, their persistence, as well as biocorrosion in areas of active bone formation can be a trigger for the development of an aseptic inflammatory process. This effect is due to both a direct damaging factor and an indirect effect through specific signal molecules produced in response to tissue damage.

show abstract