Cell molecular computers and biological information as the foundation of nature's laws

Liberman, E. A.; Minina, S.V.

doi:10.1016/0303-2647(95)01588-4

Cited by 33 publications

(15 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pattern of anticipatory behaviour thus approaches the condition of its optimality, i.e. it occurs by choosing the optimal coordinate scale which corresponds to the principle of optimum prediction as it was formulated by Liberman (1989); see also Liberman and Minina (1996). This principle generalizes the principle of relativity when the effect of measurement and the modelling on predicted results cannot be neglected and introduces the choice of most optimal coordinate scale in the search for best anticipatory solutions.…”

Section: The Role Of Splicing In Anticipatory Dynamicsmentioning

confidence: 95%

Anticipatory dynamics of biological systems: from molecular quantum states to evolution

Igamberdiev

2015

International Journal of General Systems

View full text Add to dashboard Cite

Living systems possess anticipatory behaviour that is based on the flexibility of internal models generated by the system's embedded description. The idea was suggested by Aristotle and is explicitly introduced to theoretical biology by Rosen. The possibility of holding the embedded internal model is grounded in the principle of stable non-equilibrium (Bauer). From the quantum mechanical view, this principle aims to minimize energy dissipation in expense of long relaxation times. The ideas of stable non-equilibrium were developed by Liberman who viewed living systems as subdivided into the quantum regulator and the molecular computer supporting coherence of the regulator's internal quantum state. The computational power of the cell molecular computer is based on the possibility of molecular rearrangements according to molecular addresses. In evolution, the anticipatory strategies are realized both as a precession of phylogenesis by ontogenesis (Berg) and as the anticipatory search of genetic fixation of adaptive changes that incorporates them into the internal model of genetic system. We discuss how the fundamental ideas of anticipation can be introduced into the basic foundations of theoretical biology.

show abstract

Section: The Role Of Splicing In Anticipatory Dynamicsmentioning

confidence: 95%

Anticipatory dynamics of biological systems: from molecular quantum states to evolution

Igamberdiev

2015

International Journal of General Systems

View full text Add to dashboard Cite

show abstract

“…Despite the conceptual importance of this view, at present, few investigators would easily accept that there is more than a crude metaphor behind the analogy between cells and computers (see, however, Liberman, 1979; Yockey, 1992; Danchin, 1996; Liberman & Minina, 1996; Maynard-Smith, 2000). Yet the literature exploring the conjecture that the genetic program is more than a metaphor, and that cells, bacteria in particular, are Turing machines [i.e.…”

Section: Introductionmentioning

confidence: 99%

Bacteria as computers making computers

2009

View full text Add to dashboard Cite

Various efforts to integrate biological knowledge into networks of interactions have produced a lively microbial systems biology. Putting molecular biology and computer sciences in perspective, we review another trend in systems biology, in which recursivity and information replace the usual concepts of differential equations, feedback and feedforward loops and the like. Noting that the processes of gene expression separate the genome from the cell machinery, we analyse the role of the separation between machine and program in computers. However, computers do not make computers. For cells to make cells requires a specific organization of the genetic program, which we investigate using available knowledge. Microbial genomes are organized into a paleome (the name emphasizes the role of the corresponding functions from the time of the origin of life), comprising a constructor and a replicator, and a cenome (emphasizing community-relevant genes), made up of genes that permit life in a particular context. The cell duplication process supposes rejuvenation of the machine and replication of the program. The paleome also possesses genes that enable information to accumulate in a ratchet-like process down the generations. The systems biology must include the dynamics of information creation in its future developments.

show abstract

“…Yet the very success of molecular biology pinpointing individual components and partial functions will finally precipitate another type of approaches that we may epitomize as molecular parallels of the above reviewed duality theory. The workings of Fox (1988), Kampis (1991), Albrecht-Buehler (1990), Welch (1992), Igamberdiev (1994), Liberman and Minina (1996), Conrad (1996), and of some others preclude such new orientations.…”

Section: Life and Information: Recapitulatingmentioning

confidence: 96%

The topological inventions of life: From the specialization of multicellular colonies to the functioning of the vertebrate brain

Marijuán¹

1997

World Futures

View full text Add to dashboard Cite

The evolution of biological (intermediary) complexity strongly depends upon the information-processing advantages it confers to cells and organisms. As a matter of fact, highly complex biological structures such as the cellular signaling system and the vertebrate nervous system have been evolved in order to inform the living system about its surround, subsequently orienting the internal, productive activities. The evolutionary success of these types of informational structures ("infostructures") exemplifies that, almost universally, the "bit" may act as a successful substitute for the "joule". Recent molecular biology research on cellular signaling systems has disclosed their amazing information-processing sophistication and the crucial role they play in the formation and functioning of the vertebrate brain. In the neurosciences, duality theory has highlighted the way in which the cortical maps and the cerebral substructures of the vertebrate brain are "topologically" integrated in order to perform an adaptive informationprocessing. The development of comprehensive conceptualizations relating brain processing and intracellular processing may well be a strategic step in the development of a vertical "information science".

show abstract

Cell molecular computers and biological information as the foundation of nature's laws

Cited by 33 publications

References 3 publications

Anticipatory dynamics of biological systems: from molecular quantum states to evolution

Anticipatory dynamics of biological systems: from molecular quantum states to evolution

Bacteria as computers making computers

The topological inventions of life: From the specialization of multicellular colonies to the functioning of the vertebrate brain

Contact Info

Product

Resources

About