Cell metabolomics identify regulatory pathways and targets of magnoline against prostate cancer

Sun, Hui; Zhang, Aihua; Liu, Shaobo; Qiu, Shi; Li, Xianna; Zhang, Tianlei; Liu, Liang; Wang, Xijun

doi:10.1016/j.jchromb.2018.10.017

Cited by 47 publications

(32 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Untargeted metabolomics has been used to discover the metabolite biomarkers of diseases for disease diagnosis, 34-41 pathological mechanisms, 42-53 and therapeutic effects. [54][55][56][57][58][59] Liquid chromatography-mass spectrometry (LC-MS) is widely used in metabolic analysis. [60][61][62][63][64][65][66][67][68][69][70][71] It can monitor small molecule metabolites changes in biological samples.…”

Section: Discussionmentioning

confidence: 99%

Comparative metabolomics unveils molecular changes and metabolic networks of syringin against hepatitis B mice by untargeted mass spectrometry

Jiang

Zhou

et al. 2020

RSC Adv.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Comparative metabolomics unveils molecular changes and metabolic networks of syringin against hepatitis B mice by untargeted mass spectrometry

Jiang

Zhou

et al. 2020

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…Mass spectrometry-based metabolomics has enabled the discovery of many biomarkers and provides insight into pathogenesis, disease diagnosis, 56-75 treatment prognosis, [76][77][78][79][80] and monitoring testing. [81][82][83][84][85][86][87] Some researchers have found that amino acids are the nal metabolites of proteins.…”

Section: Discussionmentioning

confidence: 99%

Ultra-performance liquid chromatography-mass spectrometry-based metabolomics reveals Huangqiliuyi decoction attenuates abnormal metabolism as a novel therapeutic opportunity for type 2 diabetes

Jiang

Liu

et al. 2019

RSC Adv.

View full text Add to dashboard Cite

Background: As a typical chronic metabolic disease, type 2 diabetes mellitus causes a heavy health-care burden to society. In this study, we applied the metabolomics strategy to explore the potential molecular mechanism of the Huangqiliuyi decoction (HQLYD) for type-2 diabetes (T2D). Ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) combined with pattern recognition methods was utilized to select specific metabolites closely associated with HQLYD. Biomarker pathway analysis and biological network were utilized to uncover the therapeutic effect and action mechanism related to HQLYD. A total of twenty-five biomarkers were identified in the animal model, in which sixteen biomarkers are associated with HQLYD treatment for T2D. They attenuated the abnormalities of metabolic pathways such as phenylalanine, tyrosine and tryptophan biosynthesis, phenylalanine metabolism, and the citrate cycle. HQLYD also significantly elevated the serum FINS and SOD, GSP-x level in the liver and kidney, and reduced the serum TC, TG, HDL, LDL, urea, Scr, AST, ALT, FBG, IRS, MDA, and CAT level. We found that the therapeutic mechanism of HQLYD against T2D affected amino acid metabolism, glucose metabolism and lipid metabolism. Metabolomics revealed that the Huangqiliuyi decoction attenuates abnormal metabolism as a novel therapeutic opportunity for type 2 diabetes.

show abstract

“…Magnoline is the primary compound derived from Cortex Phellodendri amurensis, which exhibits significant therapeutic potential for PCa. Sun et al conducted a UPLC-MS metabolomics of 22RV1 cells in vitro on PCa [40]. It was found that magnoline markedly restored the energy metabolism, amino acid metabolism, and fatty acid metabolism, which revealed that cancer cells may result in death because of insufficient material basis to favor their rapid proliferation.…”

Section: Review On Metabolism-targeting Chinese Medicine Treatment Onmentioning

confidence: 99%

Chinese Medicines for Cancer Treatment from the Metabolomics Perspective

Guo¹,

Tan²,

Wang³

et al. 2020

Metabolomics - New Insights Into Biology and Medicine

View full text Add to dashboard Cite

Cancer is one of the most prevalent diseases all over the world with poor prognosis and the development of novel therapeutic strategies is still urgently needed. The large amount of successful experiences in fighting against cancer-like diseases with Chinese medicine has suggested it as a great source of alternative treatments to human cancers. Cancer cells have been shown to own a predominantly unique metabolic phenotype to facilitate their rapid proliferation. Metabolic reprogramming is a remarkable hallmark of cancer and therapies targeting cancer metabolism can be highly specific and effective. Based on the sophisticated study of small molecule metabolites, metabolomics can provide us valuable information on dynamically metabolic responses of living systems to certain environmental condition. In this chapter, we systematically reviewed recent studies on metabolism-targeting anticancer therapies based on metabolomics in terms of glucose, lipid, amino acid, and nucleotide metabolisms and other altered metabolisms, with special emphasis on the potential of metabolic treatment with pure compounds, herb extracts, and formulations from Chinese medicines. The trends of future development of metabolism-targeting anticancer therapies were also discussed. Overall, the elucidation of the underlying molecular mechanism of metabolism-targeting pharmacologic therapies will provide us a new insight to develop novel therapeutics for cancer treatment.

show abstract

Cell metabolomics identify regulatory pathways and targets of magnoline against prostate cancer

Cited by 47 publications

References 20 publications

Comparative metabolomics unveils molecular changes and metabolic networks of syringin against hepatitis B mice by untargeted mass spectrometry

Comparative metabolomics unveils molecular changes and metabolic networks of syringin against hepatitis B mice by untargeted mass spectrometry

Ultra-performance liquid chromatography-mass spectrometry-based metabolomics reveals Huangqiliuyi decoction attenuates abnormal metabolism as a novel therapeutic opportunity for type 2 diabetes

Chinese Medicines for Cancer Treatment from the Metabolomics Perspective

Contact Info

Product

Resources

About