Cell Membrane State, Permeability, and Elasticity Assessment for Single Cells and Cell Ensembles

Färber, Nicolas; Neidinger, Simon; Westerhausen, Christoph

doi:10.1007/978-1-0716-3052-5_14

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Ion Permeation Across Membranes and Membrane Defects1

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2023

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“…It requires a molecular understanding of the collective response of the membrane that may include a large number of atoms and degrees of freedom. Ideas vary from ignoring membrane coordinates since they are fast compared to the ion translocation to collective continuum modes of membrane bending 33 and to local defects of range-limited membrane distortion 25 with several phospholipids and proximate water solvation.…”

Section: Ion Permeation Across Membranes and Membrane Defectsmentioning

confidence: 99%

Defect Formation and Peptide Permeation across Phospholipid Membranes

Elber

2023

J. Phys. Chem. B

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Cell penetrating peptides (CPPs) are natural agents that efficiently permeate biological membranes. They are frequently positively charged, which is surprising since membranes pose hydrophobic barriers. In this Perspective, I discuss computations and experiments of a permeation model that couples permeant displacement with a membrane defect. We call the proposed mechanism Defect Assisted by Charge (DAC) and illustrate that it reduces the free energy barrier for translocation. A metastable state at the center of the membrane may be observed due to the charge interactions with the phospholipid head groups at the two leaflets. The combination of experiments and simulations sheds light on the mechanisms of a charged peptide translocation across phospholipid membranes.

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Section: Ion Permeation Across Membranes and Membrane Defectsmentioning

confidence: 99%

Defect Formation and Peptide Permeation across Phospholipid Membranes

Elber

2023

J. Phys. Chem. B

View full text Add to dashboard Cite

show abstract

Cell Membrane State, Permeability, and Elasticity Assessment for Single Cells and Cell Ensembles

Cited by 1 publication

References 13 publications

Defect Formation and Peptide Permeation across Phospholipid Membranes

Defect Formation and Peptide Permeation across Phospholipid Membranes

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