Abstract:The aim of the present work was to develop simple modification technique for polyurethanes (PUs) intended for use in blood-contacting implants (vascular grafts, heart prosthesis, ventricular assist devices). PU surface was modified with soybean-derived phosphatidylcholine (PC) via one-step dip coating technique. In order to evaluate blood compatibility of the obtained materials, samples were contacted with human blood under static and arterial flow-simulated conditions. The PC-modified surfaces were thoroughly… Show more
“…Apart from lecithin presence, the results of chemical composition analysis of nHAp-PC are comparable with results obtained for other methods for synthesis of nanoparticles of hydroxyapatite [ 20 , 23 ]. Biocompatibility of lecithin is well established in the literature [ 24 , 25 ]; thus, its presence in the synthesized nHAp-PC might be preferable for its biomedical applications. Fig.…”
Section: Resultsmentioning
confidence: 99%
“…This effect might be observed even when surfactants are bonded or adsorbed on the biomaterial surface. Lecithin—mixture of phosphatidylcholines, components of cellular membranes [ 24 ]—when present on the surface of any biomaterial, attracts cells to interact with the material without causing any damage to the cell membrane [ 25 ]. Aforementioned reported approaches to wet chemical precipitation allow to affect the particles morphology, but only in range from nanorods to nanopheres.…”
Hydroxyapatite Ca10(PO4)6(OH)2 nanoparticles have been successfully synthesized by the wet chemical precipitation method at 60 °C in the presence of biocompatible natural surfactant—lecithin. The composition and morphology of nanoparticles of hydroxyapatite synthesized with lecithin (nHAp-PC) was studied by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Size distribution for nanoparticles was measured by nanoparticle tracking analysis in NanoSight system. We discuss in details influence of lecithin concentration in reaction system on nHAp-PC morphology, as well as on size distributions and suspendability of nanoparticles. Product exhibits crystalline structure and chemical composition of hydroxyapatite, with visible traces of lecithin. Difference in surfactant amounts results in changes in particles morphology and their average size.
“…Apart from lecithin presence, the results of chemical composition analysis of nHAp-PC are comparable with results obtained for other methods for synthesis of nanoparticles of hydroxyapatite [ 20 , 23 ]. Biocompatibility of lecithin is well established in the literature [ 24 , 25 ]; thus, its presence in the synthesized nHAp-PC might be preferable for its biomedical applications. Fig.…”
Section: Resultsmentioning
confidence: 99%
“…This effect might be observed even when surfactants are bonded or adsorbed on the biomaterial surface. Lecithin—mixture of phosphatidylcholines, components of cellular membranes [ 24 ]—when present on the surface of any biomaterial, attracts cells to interact with the material without causing any damage to the cell membrane [ 25 ]. Aforementioned reported approaches to wet chemical precipitation allow to affect the particles morphology, but only in range from nanorods to nanopheres.…”
Hydroxyapatite Ca10(PO4)6(OH)2 nanoparticles have been successfully synthesized by the wet chemical precipitation method at 60 °C in the presence of biocompatible natural surfactant—lecithin. The composition and morphology of nanoparticles of hydroxyapatite synthesized with lecithin (nHAp-PC) was studied by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Size distribution for nanoparticles was measured by nanoparticle tracking analysis in NanoSight system. We discuss in details influence of lecithin concentration in reaction system on nHAp-PC morphology, as well as on size distributions and suspendability of nanoparticles. Product exhibits crystalline structure and chemical composition of hydroxyapatite, with visible traces of lecithin. Difference in surfactant amounts results in changes in particles morphology and their average size.
“…The dip‐coating technique is a conventional coating procedure that is normally used in coronary stent for drug eluting applications and to create a biocompatible surface in order to improve hemocompatibility . It is well known to be a simple and fast one‐step method with minimal requirements.…”
Biocompatible polymeric coatings for metallic stents are desired, as currently used materials present limitations such as deformation during degradation and exponential loss of mechanical properties after implantation. These concerns, together with the present risks of the drug-eluting stents, namely, thrombosis and restenosis, require new materials to be studied. For this purpose, novel poly(polyol sebacate)-derived polymers are investigated as coatings for metallic stents. All pre-polymers reveal a low molecular weight between 3000 and 18 000 g mol . The cured polymers range from flexible to more rigid, with E-modulus between 0.6 and 3.8 MPa. Their advantages include straightforward synthesis, biodegradability, easy processing through different scaffolding techniques, and easy transfer to industrial production. Furthermore, electrospraying and dip-coating procedures are used as proof-of-concept to create coatings on metallic stents. Biocompatibility tests using adipose stem cells lead to promising results for the use of these materials as coatings for metallic coronary stents.
“…13 Finally, a strong decrease in the platelet adhesion was shown by microscopic images, and this once again confirmed the enhanced blood compatibility of the steam-modified mPE surface. 30,32 The number of platelets adhered on the steam-treated mPE sample was lower than the number of platelets found on the hydrochloric acid treated mPE sample. 10 This further confirmed that steam treatment is a powerful surface modification technique that produces optimistic changes in mPE and making it as a promising candidate for blood-contacting devices and implants.…”
Steam treatment is a green surface modification technique that was used to improve the surface characteristics and hemocompatibility of metallocene polyethylene (mPE). In this study, a sharp decrease in the mean contact angle of steam-exposed mPE compared to that of untreated mPE showed enhanced hydrophilicity. The increased surface roughness was demonstrated by atomic force microscopy, scanning electron microscopy, and Hirox three-dimensional microscopy. The average roughness of the control mPE (2.757 nm) was enhanced to 8.753 nm by steam treatment. Fourier transform infrared spectroscopy analysis illustrated no chemical changes, but the changes in the absorbance intensity ensured morphological changes. Blood compatibility studies were assessed by coagulation assays, hemolysis, and platelet adhesion tests. The mean number of platelets adhered to the steam-treated sample (11) was half of the number of platelets adhered to the untreated mPE surface (22). The clotting time on the steam exposed surface was delayed, hemolysis and platelet adhesion were significantly reduced. The green surface modification of mPE with steam enhanced its surface properties and hemocompatibility. The improved blood compatibility of mPE may help in the efficient designing of hemocompatible biomaterials such as cardiovascular implants.
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